Direct brain recordings suggest a causal subsequent-memory effect.
Direct brain recordings suggest a causal subsequent-memory effect.
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直接大脑记录表明存在因果后续记忆效应。
DOI：
10.1093/cercor/bhad008
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Kahana,MichaelJ
中科院分区：
文献类型：
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作者：
Rubinstein,DanielY;Weidemann,ChristophT;Sperling,MichaelR;Kahana,MichaelJ
大脑状态的内源性变化和刺激特异性诱发活动都有助于成功的编码。然而，以前的研究并没有明确区分这些成分。我们通过分析癫痫患者在学习和随后回忆单词列表时记录的颅内EEG来解决这个问题。我们首先训练分类器来预测单个项目或整个列表的召回，并发现这两个分类器表现出相似的性能。我们发现，列表级分类器输出-成功编码的生物标志物-跟踪项目呈现和回忆事件，尽管没有关于试验结构的信息。在广泛的大脑区域中，低频活动（HFA）的减少和高频活动（HFA）的增加标志着项目和列表的成功编码。我们发现海马和前额叶皮层的区域差异，其中在海马HFA与项目回忆更强的相关性，而在前额叶皮层，HFA与列表性能更强。尽管在项目和列表级功能的细微差异，在整体分类性能的相似性，成功的回忆和频谱活动的波动频谱签名整个编码期间主张共享的内源性过程，因果关系影响大脑的学习新信息的能力。
Endogenous variation in brain state and stimulus-specific evoked activity can both contribute to successful encoding. Previous studies, however, have not clearly distinguished among these components. We address this question by analysing intracranial EEG recorded from epilepsy patients as they studied and subsequently recalled lists of words. We first trained classifiers to predict recall of either single items or entire lists and found that both classifiers exhibited similar performance. We found that list-level classifier output—a biomarker of successful encoding—tracked item presentation and recall events, despite having no information about the trial structure. Across widespread brain regions, decreased low- and increased high-frequency activity (HFA) marked successful encoding of both items and lists. We found regional differences in the hippocampus and prefrontal cortex, where in the hippocampus HFA correlated more strongly with item recall, whereas, in the prefrontal cortex, HFA correlated more strongly with list performance. Despite subtle differences in item- and list-level features, the similarity in overall classification performance, spectral signatures of successful recall and fluctuations of spectral activity across the encoding period argue for a shared endogenous process that causally impacts the brain’s ability to learn new information.