Association of Postburn Fatty Acids and Triglycerides with Clinical Outcome in Severely Burned Children
Association of Postburn Fatty Acids and Triglycerides with Clinical Outcome in Severely Burned Children
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DOI：
10.1210/jc.2012-2599
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发表时间：
2013-01-01
影响因子：
5.8
通讯作者：
Jeschke, Marc G.
中科院分区：
文献类型：
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作者：
Kraft, Robert;Herndon, David N.;Jeschke, Marc G.
背景：游离脂肪酸(FFAs)和甘油三酯(TGS)在烧伤后发生改变，但这些改变是否与烧伤后的预后相关尚不清楚。目的：本研究的目的是分析儿童烧伤患者的脂代谢特征，并将其与患者结局和住院病程相关联。设计和背景：我们在一家学术的儿科医院烧伤中心进行了一项前瞻性队列研究。患者：我们的研究包括219名儿童烧伤患者。主要观察指标：根据血浆TG和FFA水平对患者进行分层。分析两组患者的主要预后，如烧伤后的发病率和死亡率，以及临床代谢指标。TGS升高的患者的临床预后明显恶化，与急性期蛋白质合成增加有关，表明炎症和高代谢，而FFA的增加似乎并没有深刻改变烧伤后的结果。结论：TGS的升高与器官功能和临床结果的恶化有关，而FFA的升高与烧伤后的器官功能和临床结果无关。(临床内分泌代谢酶98：314-321,2013)
Context: Free fatty acids (FFAs) and triglycerides (TGs) are altered postburn, but whether these alterations are associated with postburn outcomes is not clear.Objective: The aim of the present study was to analyze lipid metabolic profiles in pediatric burn patients and to correlate these profiles with patient outcomes and hospital courses.Design and Setting: We conducted a prospective cohort study at an academic pediatric hospital burn center.Patients: Our study included 219 pediatric burn patients.Main Outcome Measures: Patients were stratified according to their plasma TG and FFA levels. Main patient outcomes, such as postburn morbidity and mortality, and clinical metabolic markers were analyzed.Results: All groups were similar in demographics and injury characteristics. Patients with elevated TGs had significantly worse clinical outcomes associated with increased acute-phase protein synthesis indicating augmented inflammation and hypermetabolism, whereas increased FFAs did not seem to profoundly alter postburn outcomes.Conclusions: Elevated TGs, but not FFAs, postburn are associated with worsened organ function and clinical outcomes. (J Clin Endocrinol Metab 98: 314-321, 2013)