Free choice activates a decision circuit between frontal and parietal cortex
Free choice activates a decision circuit between frontal and parietal cortex
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DOI：
10.1038/nature06849
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发表时间：
2008-05-15
期刊：
影响因子：
64.8
通讯作者：
Andersen, Richard A.
中科院分区：
文献类型：
--
作者：
Pesaran, Bijan;Nelson, Matthew J.;Andersen, Richard A.
我们经常面临我们可以自由选择的选择。为选择一个替代方案而规划运动涉及额叶和顶叶皮层（1-11）中的几个区域，这些区域在解剖学上连接成长程回路（12）。这些区域必须协调它们的活动，以选择一个共同的运动目标，但神经回路如何做出决定仍然知之甚少。本研究同时记录额叶背侧运动前区（PMd）和顶叶到达区（PRR）的信号，以探讨决策的神经回路机制。我们发现，当猴子自由地做出选择时，这些区域之间的尖峰和局部场电位（LFP）活动的相关性比它们遵循指令时更大。我们提出，一个决定电路具有细胞在额叶和顶叶皮层的亚群可能会交换信息，以协调这些领域之间的活动。参与这个决定回路的细胞可能会通过对运动目标的选择提供共同的偏置来影响运动选择。
We often face alternatives that we are free to choose between. Planning movements to select an alternative involves several areas in frontal and parietal cortex(1-11) that are anatomically connected into long-range circuits(12). These areas must coordinate their activity to select a common movement goal, but how neural circuits make decisions remains poorly understood. Here we simultaneously record from the dorsal premotor area (PMd) in frontal cortex and the parietal reach region (PRR) in parietal cortex to investigate neural circuit mechanisms for decision making. We find that correlations in spike and local field potential (LFP) activity between these areas are greater when monkeys are freely making choices than when they are following instructions. We propose that a decision circuit featuring a sub-population of cells in frontal and parietal cortex may exchange information to coordinate activity between these areas. Cells participating in this decision circuit may influence movement choices by providing a common bias to the selection of movement goals.