Clinical and Pathologic Profiles of Esophageal Cancer in Mozambique: A Study of Consecutive Patients Admitted to Maputo Central Hospital.
Clinical and Pathologic Profiles of Esophageal Cancer in Mozambique: A Study of Consecutive Patients Admitted to Maputo Central Hospital.
复制标题
DOI：
10.1200/jgo.18.00147
复制
发表时间：
2018-11
影响因子：
--
通讯作者：
Santos LL
中科院分区：
文献类型：
--
作者：
Come J;Castro C;Morais A;Cossa M;Modcoicar P;Tulsidâs S;Cunha L;Lobo V;Morais AG;Cotton S;Lunet N;Carrilho C;Santos LL
东非最近被描述为食道癌的高发地理区域。莫桑比克是该地区的一部分。这项研究旨在描述马普托中心医院(MCH)这种恶性疾病的特征，以制定莫桑比克食道癌管理的全球计划。使用2012至2016年间的妇幼保健记录来评估食道肿瘤的临床、病理和预后特征。对收集到的数据进行描述性分析。采用Kaplan-Meier曲线评价患者的总体生存率。在这项研究中，连续记录了522例食道癌患者。患者年龄中位数为56.1岁(27-97岁)，女性291例(55.7%)，男性230例(44.1%)。肿瘤部位位于下1/3者113例(21.6%)，中段154例(29.5%)，上1/3者50例(9.6%)，其余196例(37.5%)肿瘤部位不明。鳞状细胞癌占记录的组织病理学病例的94.4%(占样本的74.9%)。手术治疗32例(6.1%)。仅在这32名手术患者中记录到疾病分期；分别有28.1%、53.1%和18.8%的患者有I、II和III期疾病。其余患者似乎涉及临床晚期肿瘤。中位随访时间为1.6个月。所有患者的中位生存期为3.5个月；有治疗意图的患者为8.7个月。食道癌是妇幼保健院常见的恶性肿瘤，确诊时已进入晚期，预后不良。因此，在莫桑比克实施食道癌计划至关重要。
Eastern Africa was recently described as a high-incidence geographic area for esophageal cancer. Mozambique is included in this region. This study aimed to characterize this malignant disease at Maputo Central Hospital (MCH) to develop a global program for esophageal cancer management in Mozambique. MCH records from between 2012 and 2016 were used to assess the clinical, pathologic, and outcome profiles of esophageal tumors. A descriptive analysis of data collected was performed. Overall survival was evaluated using Kaplan-Meier curves. In the study, 522 consecutive patient cases of esophageal cancer were recorded. The median patient age was 56.1 years (range, 27 to 97 years); 291 (55.7%) patients were women, and 230 (44.1%) were men. Regarding tumor site, 113 patients (21.6%) had a tumor in the lower third, 154 (29.5%) in the middle, and 50 (9.6%) in the upper third of the esophagus; in the remaining 196 (37.5%), tumor site was unknown. Squamous cell carcinoma comprised 94.4% of cases with documented histopathology (74.9% of the sample). Surgical treatment was possible in 32 patients (6.1%). Disease stage was documented only in these 32 surgical patients; 28.1%, 53.1%, and 18.8% had stage I, II, and III disease, respectively. The remaining patient cases seemed to involve clinically advanced tumors. The median follow-up time was of 1.6 months. The median survival time was of 3.5 months for all patients; for patients treated with curative intent, it was of 8.7 months. Esophageal carcinoma is a common malignant tumor at MCH and is diagnosed in the advanced stages resulting in poor prognosis. Therefore, implementation of an Esophageal Cancer Program in Mozambique is essential.