ASSESSMENT OF FRONTAL-LOBE FUNCTIONING IN SCHIZOPHRENIA AND UNIPOLAR MAJOR DEPRESSION
ASSESSMENT OF FRONTAL-LOBE FUNCTIONING IN SCHIZOPHRENIA AND UNIPOLAR MAJOR DEPRESSION
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DOI：
10.1159/000284803
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发表时间：
1993-03-01
期刊：
影响因子：
3.6
通讯作者：
HAIN, C
中科院分区：
文献类型：
--
作者：
FRANKE, P;MAIER, W;HAIN, C
这项研究使用了神经心理学任务——威斯康星卡片分类（WCST）、追踪（TMT）A和B、语言流畅性、数字广度——来比较急性和目前停止用药的精神分裂症患者、单相非精神病性重度抑郁症患者和健康对照。两组患者的神经心理学表现均与健康对照组存在显着差异。此外，在额叶相关任务：WCST 中，精神分裂症患者和抑郁症患者之间只有很小的（定量）差异。 TMT 和言语流利度。抑郁症患者在“数字广度”方面的表现往往比精神分裂症患者差，这项任务被假设涉及大脑额叶以外的区域。尽管抑郁症患者组比精神分裂症患者年龄更大，但年龄的影响可能无法完全解释这些发现。结果表明，精神分裂症和抑郁症患者的额叶认知功能确实存在紊乱。精神分裂症组的症状学 (SANS/SAPS) 和认知功能仅显示阴性症状与 WCST 中表现较差相关，但与 TMT 中的阴性和阳性症状显着相关。
This study has used neuropsychological tasks - Wisconsin Card Sort (WCST), Trail Making (TMT) A and B, Verbal Fluency, Digit Span - to compare acute and currently off-medication schizophrenics, patients with unipolar nonpsychotic major depression and healthy controls. Both patient groups differed significantly from healthy controls in their neuropsychological performance. Furthermore there was only little (quantitative) difference between schizophrenics and depressed patients in the frontal lobe associated tasks: WCST. TMT and Verbal Fluency. Depressed patients tended to perform worse than schizophrenics on Digit Span, a task hypothesized to involve other than frontal areas of the brain. Although the group of depressed patients was older than the schizophrenic sample, the effect of age may not totally explain the findings. The results indicate that there do exist disturbances in frontal lobe cognitive functioning in schizophrenia and depression. Symptomatology (SANS/SAPS) and cognitive functioning in the schizophrenic group revealed only a trend for negative symptoms to be associated with worse performance in the WCST, but were significantly correlated with negative as well as positive symptoms on the TMT.