Coatings of molecularly imprinted polymers based on polyhedral oligomeric silsesquioxane for open tubular capillary electrochromatography
Coatings of molecularly imprinted polymers based on polyhedral oligomeric silsesquioxane for open tubular capillary electrochromatography
复制标题
用于开管毛细管电色谱的基于多面体低聚倍半硅氧烷的分子印迹聚合物涂层
DOI：
10.1016/j.talanta.2016.02.019
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发表时间：
2016
期刊：
影响因子：
6.1
通讯作者：
Liu Zhao-Sheng
中科院分区：
文献类型：
--
作者：
Zhao Qing-Li;Zhou Jin;Zhang Li-Shun;Huang Yan-Ping;Liu Zhao-Sheng
首次成功地将多面体低聚硅氧烷（POSS）用于制备毛细管电色谱印迹整体涂层。以PSS-（1-甲基丙烯酸丙酯）-庚异丁基取代（MA 0702）、s -氨氯地平（模板）、甲基丙烯酸（功能单体）和2-甲基丙烯酰胺丙酯（交联剂）为原料，在甲苯-异辛烷的致孔混合物中合成了印迹单片涂层。考察了ma0702的用量、模板与单体的比例、单体与交联剂的比例等合成参数对印迹效果和分离性能的影响。用ma0702制备的印迹整体柱分离对映体的最大分辨率可达22.3，是不加POSS制备的印迹整体柱的2倍左右。基于poss的MIP涂层的柱效率超过30,000 plate m−1。在选择性、色谱柱效率和分辨率方面比较了添加POSS和不添加POSS合成的MIP涂层。用萘普生或佐匹克隆制备了基于poss的MIP毛细管，实现了对映体的分离。
Polyhedral oligomeric silsesquioxane (POSS) was successfully applied, for the first time, to prepare imprinted monolithic coating for capillary electrochromatography. The imprinted monolithic coating was synthesized with a mixture of PSS-(1-Propylmethacrylate)-heptaisobutyl substituted (MA 0702),S-amlodipine (template), methacrylic acid (functional monomer), and 2-methacrylamidopropyl methacrylate (crosslinker), in a porogenic mixture of toluene–isooctane. The influence of synthesis parameters on the imprinting effect and separation performance, including the amount of MA 0702, the ratio of template to monomer, and the ratio of monomer to crosslinker, was investigated. The greatest resolution for enantiomers separation on the imprinted monolithic column prepared with MA 0702 was up to 22.3, about 2 times higher than that prepared in absence of the POSS. Column efficiency on the POSS-based MIP coatings was beyond 30,000 plate m−1. The comparisons between MIP coating synthesized with the POSS and without the POSS were made in terms of selectivity, column efficiency, and resolution. POSS-based MIP capillaries with naproxen or zopiclone was also prepared and separation of enantiomers can be achieved.