Metabolic substrates other than glucose support axon function in central white matter
Metabolic substrates other than glucose support axon function in central white matter
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DOI：
10.1002/jnr.10081
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发表时间：
2001-12-01
影响因子：
4.2
通讯作者：
Ransom, BR
中科院分区：
文献类型：
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作者：
Brown, AM;Wender, R;Ransom, BR
我们测试了非葡萄糖能源可以支持大鼠视神经轴突功能的假设。通过监测刺激诱发的复合动作电位（CAP）评估轴突功能。CAP在10 mM葡萄糖中以全振幅维持2小时。20 mM乳酸盐、20 mM丙酮酸盐、10 mM果糖或10 mM甘露糖与葡萄糖一样有效地支持轴突功能，10 mM谷氨酰胺提供部分支持，但β-羟基丁酸盐、辛酸盐、山梨糖醇、丙氨酸、天冬氨酸盐和谷氨酸盐不能支持轴突功能.我们的研究结果表明，多种化合物可以维持中枢神经系统有髓轴突的功能。轴突可能直接使用乳酸盐、丙酮酸盐和谷氨酰胺作为能量底物，而甘露糖和果糖可以穿梭通过星形胶质细胞转化为乳酸盐，然后输出到轴突。(C)2001 Wiley-Liss，Inc.
We tested the hypothesis that non-glucose energy sources can support axon function in the rat optic nerve. Axon function was assessed by monitoring the stimulus-evoked compound action potential (CAP). CAP was maintained at full amplitude for 2 hr in 10 mM glucose. 20 mM lactate, 20 mM pyruvate, 10 mM fructose, or 10 mM mannose supported axon function as effectively as did glucose, and 10 mM glutamine provided partial support, but beta -hydroxybutyrate, octanoate, sorbitol, alanine, aspartate, and glutamate failed to support axon function. Our results indicated that a variety of compounds can sustain function in CNS myelinated axons. Axons probably use lactate, pyruvate, and glutamine directly as energy substrates, whereas mannose and fructose could be shuttled through astrocytes to lactate, which is then exported to axons. (C) 2001 Wiley-Liss, Inc.