Terphenyl derivatives and terpenoids from a wheat-born mold Aspergillus candidus
Terphenyl derivatives and terpenoids from a wheat-born mold Aspergillus candidus
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DOI：
10.1038/s41429-019-0266-9
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发表时间：
2020-03-01
影响因子：
3.3
通讯作者：
Liu, HongWei
中科院分区：
文献类型：
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作者：
Han, JunJie;Lu, FangMing;Liu, HongWei
从白色曲霉（Aspergilluscandidus）中分离得到一个新的对三联苯衍生物aspergicandidusin A（1）、一个新的二萜类化合物6-deoxyaspergiloid C（13）和12个已知化合物（2-12和14）。新化合物的结构经核磁共振谱和质谱确证。通过[Rh-2（OCOCF 3）（4）]配合物的圆二色性数据确定了13中C-1的绝对构型。化合物2-8和11对K562细胞系显示中等抑制活性，IC 50值在17.9 - 46.3 μ M范围内。化合物13对HepG 2细胞表现出中等的细胞毒性，IC 50值为47.7 μ M。化合物11和12显示出中等的抗S.金黄色葡萄球菌的MIC值为6.25 μ M。
A new p-terphenyl derivative aspergicandidusin A (1), a new cleistanthane diterpenoid 6-deoxyaspergiloid C (13), and 12 known compounds (2-12, and 14) were isolated from the mold Aspergillus candidus. The structures of the new compounds were elucidated by spectral analysis of NMR and MS data. The absolute configuration of C-1 in 13 was determined via the circular dichroism data of the [Rh-2(OCOCF3)(4)] complex. Compounds 2-8 and 11 showed moderate inhibitory activity against K562 cell lines with the IC50 value in the range from 17.9 to 46.3 mu M. Compound 13 exhibited moderate cytotoxicity against HepG2 cells with the IC50 value of 47.7 mu M. Compounds 11 and 12 exhibited moderate activity against the growth of S. aureus with MIC value of 6.25 mu M, respectively.