Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations.
Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations.
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DOI：
10.1039/c0lc00602e
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发表时间：
2011-06
期刊：
影响因子：
6.1
通讯作者：
M. Vahey;J. Voldman
中科院分区：
文献类型：
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作者：
M. Vahey;J. Voldman
放置在能量场景中的胶体粒子相互作用，产生复杂的动态行为，影响处理和操纵这些粒子悬浮液的能力。这些粒子相互作用的传播范围从10‘S粒子的局部行为到包含>；10(6)粒子的非局部行为，这些粒子相互作用无处不在，难以定量描述，特别是在微流控设备典型的受限环境中。为了更好地了解颗粒相互作用在这种情况下的影响，我们利用一个简单的微流体装置进行了实验和模拟，在该装置中，利用流体动力和静电力来浓缩和分离颗粒混合物。这些研究揭示了微米级颗粒撞击介质电泳力屏障时形成动态图案的机制：它们在恒定的操作条件下聚集和再循环的趋势，以及当操作条件改变时进行重组的趋势。这些相互作用的粒子集合的紧急行为表现出动态挫折性和协作性的特征，这表明了浓缩和分选悬浮液的非直观策略。最后，我们给出了一个简单的基于流体动力耦合的分析模型，该模型捕捉了强相互作用颗粒悬浮液的重要特征。
Colloidal particles placed in an energy landscape interact with each other, giving rise to complex dynamic behavior that affects the ability to process and manipulate suspensions of these particles. Propagating across scales ranging from the local behavior of 10's of particles to non-local behavior encompassing >10(6) particles, these particle interactions are pervasive and challenging to describe quantitatively, especially in the confined environments typical of microfluidic devices. To better understand the effects of particle interactions in this context, we have performed experiments and simulations involving a simple microfluidic device in which hydrodynamic and electrostatic forces are leveraged to concentrate and separate particle mixtures. These investigations reveal the mechanisms underlying the dynamic patterns formed by micron-scale particles as they impinge on a dielectrophoretic force barrier: their tendency to aggregate and recirculate under constant operating conditions, and to reorganize when the operating conditions are changed. The emergent behaviors of these ensembles of interacting particles exhibit features of dynamical frustration and cooperativity that suggest non-intuitive strategies for concentrating and sorting suspensions. Finally, we present a simple analytic model based on hydrodynamic coupling that captures important features of strongly interacting particle suspensions.