Overexpression of GYS1, MIF, and MYC Is Associated With Adverse Outcome and Poor Response to Azacitidine in Myelodysplastic Syndromes and Acute Myeloid Leukemia
Overexpression of GYS1, MIF, and MYC Is Associated With Adverse Outcome and Poor Response to Azacitidine in Myelodysplastic Syndromes and Acute Myeloid Leukemia
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DOI：
10.1016/j.clml.2014.10.003
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发表时间：
2015-04-01
影响因子：
2.7
通讯作者：
Perez-Simon, Jose A.
中科院分区：
文献类型：
--
作者：
Falantes, Jose F.;Trujillo, Pablo;Perez-Simon, Jose A.
分子异常对髓系恶性肿瘤的预后至关重要。我们评估了81例MDS和AML患者基因表达的影响。其中一些基因的过度表达与不良结局（GYS 1和MIF）和对阿扎胞苷（MYC）的反应较低有关。这些结果的验证可以转化为预后细化和治疗decision.Background：骨髓增生异常综合征（MDS）和急性髓系白血病（AML）的预后是非常异质性的。患者和方法：我们分析了85例MDS和AML患者队列中几个基因的预后价值。结果如下：在多变量分析中，糖原合成酶1和巨噬细胞移动抑制因子基因的过度表达具有不良后果（分别为P = 0.003和P <0.001）。此外，髓细胞瘤病癌基因的高表达与阿扎胞苷的低反应相关（P = 0.03）。结论：在目前的研究中，我们确定了一个特定的基因表达谱作为预后因素的反应阿扎胞苷和生存在MDS和AML。(C)2015 Elsevier Inc. All rights reserved.
Molecular abnormalities are critical in prognosis of myeloid malignancies. We evaluated the impact of gene expression in 81 patients with MDS and AML. Over-expression of some of these genes was related to poor outcome (GYS1 and MIF) and lower response to azacitidine (MYC). Validation of these results could translate in prognosis refinement and treatment decision.Background: The prognosis of myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML) is very heterogeneous. Patients and Methods: We analyzed the prognostic value of several genes in a cohort of 85 MDS and AML patients. Results: Overexpression of glycogen synthase 1 and macrophage migration inhibitory factor genes had an adverse outcome in multivariate analysis (P = .003 and P < .001, respectively). Furthermore, the higher expression of myelocytomatosis oncogene was associated with a lower response to azacitidine (P = .03). Conclusion: In the current study we identified a specific gene expression profile as prognostic factors for response to azacitidine and survival in MDS and AML. (C) 2015 Elsevier Inc. All rights reserved.