AN EXACT TEST FOR HARDY-WEINBERG AND MULTIPLE ALLELES
AN EXACT TEST FOR HARDY-WEINBERG AND MULTIPLE ALLELES
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DOI：
10.2307/2531534
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发表时间：
1987-12-01
期刊：
影响因子：
1.9
通讯作者：
DEMPSTER, ER
中科院分区：
文献类型：
--
作者：
LOUIS, EJ;DEMPSTER, ER
对于多个等位基因，给出了从Hardy-Weinberg平衡总体中抽取的有限样本的精确分布的算法。有限抽样分布类似于Fisher的2 × 10 - 5分布导出。2精确分布，等价于Hardy-Weinberg总体的Levene条件有限抽样分布.所提出的算法是快速计算，并允许快速替代标准方法，需要校正和近似。在IBM 3081机器上，对于三个等位基因的例子，计算时间大约为几秒钟，对于四个等位基因的例子，计算时间长达2分钟。
Algorithms for generating the exact distribution of a finite sample drawn from a population in Hardy-Weinberg equilibrium are given for multiple alleles. The finite sampling distribution is derived analogously to Fisher''s 2 .times. 2 exact distribution and is equivalent to Levene''s conditional finite sampling distribution for Hardy-Weinberg populations. The algorithms presented are fast computationally and allow for quick alternatives to standard methods requiring corrections and approximations. Computation time is on the order of a few seconds for three-allele examples and up to 2 minutes for four-allele examples on an IBM 3081 machine.