MicroRNAs-mediated epithelial-mesenchymal transition in fibrotic diseases
MicroRNAs-mediated epithelial-mesenchymal transition in fibrotic diseases
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MicroRNA介导的纤维化疾病中的上皮-间质转化
DOI：
10.1016/j.ejphar.2016.12.003
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发表时间：
2017
影响因子：
5
通讯作者：
Zheng Zhang
中科院分区：
文献类型：
--
作者：
Xiao-Zhou Zou;Ting Liu;Zhi-Cheng Gong;Chang-Ping Hu;Zheng Zhang
microRNA（miRNAs）是一类高度保守的非编码小RNA，通过翻译抑制或mRNA降解来调控基因表达。miRNAs的异常表达是包括器官纤维化在内的一系列疾病的基础。最近的证据表明，miRNA通过介导上皮-间质转化（EMT）而促进器官纤维化。鉴于EMT在纤维化中的关键作用，已经提出减轻EMT作为对抗纤维化疾病的有前景的策略。miRNA影响特定配体、受体和信号通路的表达，从而调节EMT并因此影响纤维化。本文综述了miRNAs调控EMT的机制，并重点介绍了miRNAs调控EMT在肺纤维化、肝纤维化、肾纤维化和心脏纤维化等纤维化疾病中的作用。希望对miRNA调控的EMT的功能有更全面的了解，这将有助于开发用于各种衰弱器官纤维化的新的诊断和治疗策略。
MicroRNAs (miRNAs), a large family of small and highly conserved non-coding RNAs, regulate gene expression through translational repression or mRNA degradation. Aberrant expression of miRNAs underlies a spectrum of diseases including organ fibrosis. Recent evidence suggests that miRNAs contribute to organ fibrosis through mediating epithelial-mesenchymal transition (EMT). Alleviation of EMT has been proposed as a promising strategy against fibrotic diseases given the key role of EMT in fibrosis. miRNAs impact the expression of specific ligands, receptors, and signaling pathways, thus modulating EMT and consequently influencing fibrosis. This review summarizes the current knowledge concerning how miRNAs regulate EMT and highlights the specific roles that miRNAs-regulated EMT plays in fibrotic diseases as diverse as pulmonary fibrosis, hepatic fibrosis, renal fibrosis and cardiac fibrosis. It is desirable that a more comprehensive understanding of the functions of miRNAs-regulated EMT will facilitate the development of novel diagnostic and therapeutic strategies for various debilitating organ fibrosis.