Enantioselective Cycloaddition Reactions of Ketenes Catalyzed by N-Heterocyclic Carbenes
Enantioselective Cycloaddition Reactions of Ketenes Catalyzed by N-Heterocyclic Carbenes
复制标题
N-杂环卡宾催化烯酮对映选择性环加成反应
DOI：
10.1055/s-0033-1339300
复制
发表时间：
2013-08-01
期刊：
影响因子：
2
通讯作者：
Ye, Song
中科院分区：
文献类型：
--
作者：
Chen, Xiang-Yu;Ye, Song
本文总结了我们小组最近关于开发 N-杂环卡宾 (NHC) 催化乙烯酮环加成反应的研究。 NHC被发现是乙烯酮与各种亲电子试剂（如亚胺、羰基化合物、氧氮丙啶、氧二烯和氮杂二烯）进行对映选择性[2+2]-、[2+2+2]-、[3+2]-和[4+2]-环加成反应的有效催化剂。还研究了 NHC 催化的 α,β-不饱和酰氯的 [4+2] 环加成反应。
This account summarizes recent research in our group on the development of N-heterocyclic carbene (NHC) catalyzed cycloaddition reactions of ketenes. The NHCs were found to be efficient catalysts for the enantioselective [2+2]-, [2+2+2]-, [3+2]-, and [4+2]-cycloaddition reactions of ketenes with various electrophiles, such as imines, carbonyl compounds, oxaziridines, oxodienes and azadienes. The NHC-catalyzed [4+2] cycloaddition of alpha,beta-unsaturated acyl chlorides was also investigated.