Risk factors for pre-eclampsia in Mulago Hospital, Kampala, Uganda
Risk factors for pre-eclampsia in Mulago Hospital, Kampala, Uganda
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DOI：
10.1111/j.1365-3156.2011.02926.x
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发表时间：
2012-04-01
影响因子：
3.3
通讯作者：
Okong, Pius
中科院分区：
文献类型：
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作者：
Kiondo, Paul;Wamuyu-Maina, Gakenia;Okong, Pius
目的子痫前期是孕产妇、胎儿和新生儿发病率和死亡率的重要原因。在乌干达，先兆子痫的风险因素尚未得到很好的记录。在本文中，我们描述了先兆子痫的危险因素在产前诊所在Mulago医院，坎帕拉。方法本病例对照研究进行了2008年5月1日至2009年5月1日。其中子痫前期患者207例，正常妊娠妇女352例。这些妇女年龄在15-39岁之间，胎龄在20周或以上。对调查对象的社会人口学特征、既往病史、既往和现在的产科表现进行调查（OR 3.19，95%CI：1.54-6.61），教育水平低（OR 1.67，95%CI：1.12-2.48），慢性高血压（OR 2.29，95%CI 1.12-4.66），高血压家族史（OR 2.25，95% CI：1.53-3.31）、经产（OR 2.76，95% CI：1.84-4.15）和第5段（OR 3.71，95% CI：1.84-7.45）。卫生工作者需要确定有先兆子痫风险的妇女，并对其进行适当管理，以防止与这种情况有关的孕产妇和新生儿发病率和死亡率。
Objective Pre-eclampsia contributes significantly to maternal, foetal and neonatal morbidity and mortality. The risk factors for pre-eclampsia have not been well documented in Uganda. In this paper, we describe the risk factors for pre-eclampsia in women attending antenatal clinics at Mulago Hospital, Kampala.Methods This casecontrol study was conducted from 1st May 2008 to 1st May 2009. 207 women with pre-eclampsia were the cases, and 352 women with normal pregnancy were the controls. The women were 15-39 years old, and their gestational ages were 20 weeks or more. They were interviewed about their socio-demographic characteristics, past medical history and, their past and present obstetric performances.Results The risk factors were low plasma vitamin C (OR 3.19, 95% CI: 1.54-6.61), low education level (OR 1.67, 95% CI: 1.12-2.48), chronic hypertension (OR 2.29, 95% CI 1.12-4.66), family history of hypertension (OR 2.25, 95% CI: 1.53-3.31) and primiparity (OR 2.76, 95% CI: 1.84-4.15) and para 5 (3.71, 95% CI: 1.84-7.45).Conclusion The risk factors identified are similar to what has been found elsewhere. Health workers need to identify women at risk of pre-eclampsia and manage them appropriately so as to prevent the maternal and neonatal morbidity and mortality associated with this condition.