INFLUENCE OF THE D-2 DOPAMINE RECEPTOR AGONIST QUINPIROLE ON THE ODOR DETECTION PERFORMANCE OF RATS BEFORE AND AFTER SPIPERONE ADMINISTRATION
INFLUENCE OF THE D-2 DOPAMINE RECEPTOR AGONIST QUINPIROLE ON THE ODOR DETECTION PERFORMANCE OF RATS BEFORE AND AFTER SPIPERONE ADMINISTRATION
复制标题
DOI：
10.1007/bf00451680
复制
发表时间：
1989-01-01
影响因子：
3.4
通讯作者：
RISSER, JM
中科院分区：
文献类型：
--
作者：
DOTY, RL;RISSER, JM
使用高精度嗅觉测量法和go/no-go操作任务评估了5种剂量的D-2受体激动剂喹吡罗（0.025、0.05、0.075、0.10和0.20 mg/kg IP）对21只成年雄性Long evans大鼠气味检测性能的影响。此外，用D-2受体拮抗剂螺哌隆（0.62 mg/kg IP）预处理10只大鼠，并在喹吡罗给药后监测其表现。每三天以平衡顺序给予治疗，喹吡罗注射在260次试验测试期前15分钟进行，螺哌隆注射在35分钟前进行。喹吡罗注射剂导致气味检测性能的剂量依赖性降低，如通过正确试验的百分比和非参数信号检测灵敏度指数SI所测量的。既往使用螺哌隆治疗消除了这些影响。喹吡罗对（a）启动检测反应的平均潜伏期（即，S+反应潜伏期）、（B）总疗程持续时间和（c）中止试验的数量也通过先前的螺哌隆注射消除或大大减弱。这些结果表明，D-2受体可能参与调节气味检测性能和相关行为。
The influence of five doses of the D-2 receptor agonist quinpirole (0.025, 0.05, 0.075, 0.10, and 0.20 mg/kg IP) on the odor detection performance of 21 adult male Long evans rats was assessed using high precision olfactometry and a go/no-go operant task. Additionally, ten rats were pre-treated with the D-2 receptor antagonist spiperone (0.62 mg/kg IP) and their performance monitored following quinpirole administration. Treatments were administered every third day in a counterbalanced order, with the quinpirole injections occurring 15 min before, and the spiperone injections 35 min before, the 260-trial test sessions. Quinpirole injection resulted in a dose-dependent decrease in odor detection performance, as measured by the percentage of correct trials and by the non-parametric signal detection sensitivity index SI. Prior treatment with spiperone eliminated these effects. Dose-related influences of quinpirole on (a) the average latency to initiate a detection response (i.e., the S+ response latency), (b) the total session duration and (c) the number of aborted trials were also eliminated or greatly attenuated by prior spiperone injection. These results suggest that D-2 receptors may be involved in the modulation of odor detection performance and related behaviors.