Cerebral-Cardiac Syndrome and Diabetes: Cardiac Damage After Ischemic Stroke in Diabetic State.
Cerebral-Cardiac Syndrome and Diabetes: Cardiac Damage After Ischemic Stroke in Diabetic State.
复制标题
脑心综合症和糖尿病：糖尿病状态下缺血性中风后的心脏损伤。
DOI：
10.3389/fimmu.2021.737170
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发表时间：
2021
影响因子：
7.3
通讯作者：
Zhang HF
中科院分区：
文献类型：
--
作者：
Lin HB;Li FX;Zhang JY;You ZJ;Xu SY;Liang WB;Zhang HF
脑心综合征是指各种脑损伤后的心功能障碍。缺血性脑卒中是引起CCS的主要原因，表现为心律失常、心肌损伤和心力衰竭。CCS被认为是卒中后阶段的第二大死亡原因;然而，其相关机制尚不清楚。研究表明，其可能的机制包括岛叶皮质损伤、自主神经功能失调、儿茶酚胺激增、免疫反应和全身炎症反应。值得注意的是，卒中人群的特征揭示了与糖尿病的常见合并症。糖尿病和卒中的密切相关性和因果关系指导了糖尿病在CCS中的参与。然而，糖尿病在CCS中的作用及其相应的分子机制尚未阐明。在这里，我们总结了CCS的特点和糖尿病在CCS中的潜在作用。糖尿病驱动建立了一个“启动”的炎症微环境，并进一步诱导中风后严重的全身炎症。增强的炎症被怀疑引起心脏病理学变化，从而加剧CCS。重要的是，作为炎症的关键元件，NOD样受体pyrin domain containing 3（NLRP 3）炎性体被指示在糖尿病、中风以及随后的CCS中发挥重要作用。总之，我们描述了糖尿病在CCS中的相应作用，并推测它们之间存在NLRP 3炎性体的联系。
Cerebral-cardiac syndrome (CCS) refers to cardiac dysfunction following varying brain injuries. Ischemic stroke is strongly evidenced to induce CCS characterizing as arrhythmia, myocardial damage, and heart failure. CCS is attributed to be the second leading cause of death in the post-stroke stage; however, the responsible mechanisms are obscure. Studies indicated the possible mechanisms including insular cortex injury, autonomic imbalance, catecholamine surge, immune response, and systemic inflammation. Of note, the characteristics of the stroke population reveal a common comorbidity with diabetes. The close and causative correlation of diabetes and stroke directs the involvement of diabetes in CCS. Nevertheless, the role of diabetes and its corresponding molecular mechanisms in CCS have not been clarified. Here we conclude the features of CCS and the potential role of diabetes in CCS. Diabetes drives establish a “primed” inflammatory microenvironment and further induces severe systemic inflammation after stroke. The boosted inflammation is suspected to provoke cardiac pathological changes and hence exacerbate CCS. Importantly, as the key element of inflammation, NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome is indicated to play an important role in diabetes, stroke, and the sequential CCS. Overall, we characterize the corresponding role of diabetes in CCS and speculate a link of NLRP3 inflammasome between them.