Antiinfective applications of toll-like receptor 9 agonists.
Antiinfective applications of toll-like receptor 9 agonists.
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DOI：
10.1513/pats.200701-021aw
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发表时间：
2007-07-01
期刊：
影响因子：
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通讯作者：
Krieg, Arthur M
中科院分区：
文献类型：
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作者：
Krieg, Arthur M
天然免疫系统通过高度保守的病原体表达分子的存在来检测病原体，这些分子触发了宿主的免疫防御。Toll样受体(TLR)9可检测细菌或病毒DNA中未甲基化的CpG二核苷酸，并可用含有免疫刺激“CpG基序”的合成寡核苷酸刺激用于治疗应用。TLR9激活可诱导先天免疫和获得性免疫。TLR9诱导的天然免疫激活可应用于传染病的预防或治疗，其获得性免疫增强作用可用于改进疫苗。本文重点介绍了目前对CpG寡核苷酸作用机制的认识，并概述了TLR9激动剂在感染性疾病领域的临床前数据和早期临床试验结果。
The innate immune system detects pathogens by the presence of highly conserved pathogen-expressed molecules, which trigger host immune defenses. Toll-like receptor (TLR) 9 detects unmethylated CpG dinucleotides in bacterial or viral DNA, and can be stimulated for therapeutic applications with synthetic oligodeoxynucleotides containing immune stimulatory "CpG motifs." TLR9 activation induces both innate and adaptive immunity. The TLR9-induced innate immune activation can be applied in the prevention or treatment of infectious diseases, and the adaptive immune-enhancing effects can be harnessed for improving vaccines. This article highlights the current understanding of the mechanism of action of CpG oligodeoxynucleotides, and provides an overview of the preclinical data and early human clinical trial results, applying these TLR9 agonists in the field of infectious diseases.