A Biocompatible Arginine-based Polycation.
A Biocompatible Arginine-based Polycation.
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DOI：
10.1002/adfm.201000969
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发表时间：
2011-02-08
影响因子：
19
通讯作者：
Wang, Yadong
中科院分区：
文献类型：
--
作者：
Zern, Blaine J.;Chu, Hunghao;Osunkoya, Adeboye O.;Gao, Jin;Wang, Yadong
阳离子和阴离子之间的自组装在自然界中普遍存在。重要的生物结构如染色质通常使用聚阳离子和聚阴离子之间的多价组装。合成聚阳离子的生物医学重要性源于它们对聚阴离子如核酸和硫酸乙酰肝素的亲和力。然而，合成聚阳离子的有限生物相容性阻碍了其巨大潜力的实现。通过研究生物相容性阳离子肽，我们假设生物相容性聚阳离子应该是可生物降解的，并从内源性阳离子。我们设计了一种基于精氨酸的可生物降解聚阳离子，并证明了它在体外和体内的相容性比传统的聚阳离子高出几个数量级。当L-精氨酸被D-精氨酸取代或当可生物降解的酯接头变为生物稳定的醚接头时，这种生物相容性降低。我们相信这种设计可以产生许多生物相容性的聚阳离子，这些聚阳离子可以显着推进广泛的应用，包括控释、组织工程、生物传感和医疗器械。
Self assembly between cations and anions is ubiquitous throughout nature. Important biological structures such as chromatin often use polyvalent assembly between a polycation and a polyaninon. Biomedical importance of synthetic polycations arises from their affinity to polyanions such as nucleic acid and heparan sulfate. However, the limited biocompatibility of synthetic polycations hampers the realization of their immense potential. By examining biocompatible cationic peptides, we hypothesize that a biocompatible polycation should be biodegradable and made from endogenous cations. We designed an arginine-based biodegradable polycation and demonstrated that it was orders of magnitude more compatible than conventional polycations in vitro and in vivo. This biocompatibility diminishes when L-arginine is substituted with D-arginine or when the biodegradable ester linker changes to a biostable ether linker. We believe this design can lead to many biocompatible polycations that can significantly advance a wide range of applications including controlled release, tissue engineering, biosensing, and medical devices.
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