UniProtKB/Swiss-Prot, the Manually Annotated Section of the UniProt KnowledgeBase: How to Use the Entry View
UniProtKB/Swiss-Prot, the Manually Annotated Section of the UniProt KnowledgeBase: How to Use the Entry View
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DOI：
10.1007/978-1-4939-3167-5_2
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Xenarios, Ioannis
中科院分区：
文献类型：
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作者：
Boutet, Emmanuel;Lieberherr, Damien;Xenarios, Ioannis
通用蛋白质资源（UniProt，http：www.uniprot.org）联盟是SIB瑞士生物信息学研究所（SIB）、欧洲生物信息学研究所（EBI）和蛋白质信息资源（PIR）的一项倡议，旨在为科学界提供蛋白质序列和功能信息的中心资源。UniProt联盟维护UniProt知识库（UniProtKB），每4周更新一次，以及几个补充数据库，包括UniProt参考簇（UniRef）和UniProt档案（UniParc）JiProt知识库的Swiss-Prot部分（UniProtKB/Swiss-Prot）包含从广谱生物体获得的公开可用的专业手动注释的蛋白质序列。植物蛋白质条目是在植物蛋白质组注释程序（PPAP）的框架下产生的，重点是拟南芥和水稻的特征蛋白。UniProtKB/Swiss-Prot提供的高级注释被广泛用于通过自动管道预测新可用蛋白质的注释。本章的目的是介绍UniProtKB/Swiss-Prot条目的导游。我们还将介绍与每个条目链接的一些工具和数据库。
The Universal Protein Resource (UniProt,http://www.uniprot.org) consortium is an initiative of the SIB Swiss Institute of Bioinformatics (SIB), the European Bioinformatics Institute (EBI) and the Protein Information Resource (PIR) to provide the scientific community with a central resource for protein sequences and functional information. The UniProt consortium maintains the UniProt KnowledgeBase (UniProtKB), updated every 4 weeks, and several supplementary databases including the UniProt Reference Clusters (UniRef) and the UniProt Archive (UniParc).The Swiss-Prot section of the UniProt KnowledgeBase (UniProtKB/Swiss-Prot) contains publicly available expertly manually annotated protein sequences obtained from a broad spectrum of organisms. Plant protein entries are produced in the frame of the Plant Proteome Annotation Program (PPAP), with an emphasis on characterized proteins of Arabidopsis thaliana and Oryza sativa. High level annotations provided by UniProtKB/Swiss-Prot are widely used to predict annotation of newly available proteins through automatic pipelines.The purpose of this chapter is to present a guided tour of a UniProtKB/Swiss-Prot entry. We will also present some of the tools and databases that are linked to each entry.