Retrospective cine 3He ventilation imaging under spontaneous breathing conditions: a non‐invasive protocol for small‐animal lung function imaging
Retrospective cine 3He ventilation imaging under spontaneous breathing conditions: a non‐invasive protocol for small‐animal lung function imaging
复制标题
自主呼吸条件下回顾性电影 3He 通气成像：小动物肺功能成像的非侵入性协议
DOI：
10.1002/nbm.1086
复制
发表时间：
2007
影响因子：
2.9
通讯作者：
Y. Crémillieux
中科院分区：
文献类型：
--
作者：
V. Stupar;E. Canet;S. Gaillard;H. Alsaid;N. Beckmann;Y. Crémillieux
在大鼠肺功能成像中实施并验证了用于小动物的无创和自由呼吸超极化（HP）3He成像方案。动物被允许从戴在头上的面罩和储气罐中呼吸空气和3He的混合物。采用放射状成像序列，监测MRI信号强度变化，进行回顾性电影图像重建。以100 ms的时间分辨率对动物的通气周期进行成像。应用滑动窗口成像技术重建覆盖完整呼吸周期的5 ms时移图像系列。对图像序列进行处理，以提取定量通气参数，如气体到达时间。通过对相同动物进行多次采集，评价了该通气成像方案的再现性和无创性。版权所有© 2006约翰威利父子有限公司。
A non‐invasive and free‐breathing hyperpolarized (HP) 3He imaging protocol for small animals was implemented and validated on rats for lung function imaging. Animals were allowed to breathe a mixture of air and 3He from a mask and a gas reservoir fitted to their heads. Radial imaging sequences were used, and MRI signal intensity changes were monitored for retrospective cine image reconstruction. The ventilation cycle of the animals was imaged with a 100 ms temporal resolution. The sliding window imaging technique was applied to reconstruct 5 ms time‐shifted image series covering the complete breathing cycle. Image series were processed to extract quantitative ventilation parameters such as the gas arrival time. The reproducibility and the non‐invasiveness of this ventilation imaging protocol were evaluated by multiple acquisitions on the same animals. Copyright © 2006 John Wiley & Sons, Ltd.