Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multicentre clinical trial
Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multicentre clinical trial
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DOI：
10.1136/ard.2007.076919
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发表时间：
2008-12-01
影响因子：
27.4
通讯作者：
Le Graverand, M-P Hellio
中科院分区：
文献类型：
--
作者：
Eckstein, F.;Buck, R. J.;Le Graverand, M-P Hellio
目的：软骨形态定量磁共振成像(QMRI)是治疗骨关节炎(DMOAD)药物开发的一种有前景的工具。最近在单个地点的研究表明，在3.0特斯拉(T)下的测量比在1.5 T下的测量更具重复性(精确度)，然而，使用不同供应商的成像设备进行多中心研究的精度误差和稳定性尚未得到评估。方法：使用西门子Magnetom Trio和GE Signa Excite磁体在7个临床中心对158名女性参与者(97 Kellgren和Lawrence分级(KLG)0，31 KLG 2和30 KLG 3)进行成像。在基线和3个月时采用水激发破坏梯度回波序列(分辨率为1.0x0.31×0.31 mm(3))进行双斜冠状采集。结果：所有受试者测量软骨厚度/体积的精度误差(均方根变异系数)分别为2.1%/2.4%(胫骨内侧)和2.9%/3.3%(股骨外侧负重)。在KLG、成像地点或扫描仪制造商/类型之间没有观察到显著的精度误差差异。基线和3个月之间的平均差异范围为
Objective: Quantitative MRI (qMRI) of cartilage morphology is a promising tool for disease-modifying osteoarthritis drug (DMOAD) development. Recent studies at single sites have indicated that measurements at 3.0 Tesla (T) are more reproducible ( precise) than those at 1.5 T. Precision errors and stability in multicentre studies with imaging equipment from various vendors have, however, not yet been evaluated.Methods: A total of 158 female participants (97 Kellgren and Lawrence grade (KLG) 0, 31 KLG 2 and 30 KLG 3) were imaged at 7 clinical centres using Siemens Magnetom Trio and GE Signa Excite magnets. Double oblique coronal acquisitions were obtained at baseline and at 3 months, using water excitation spoiled gradient echo sequences (1.0x0.31x0.31 mm(3) resolution). Segmentation of femorotibial cartilage morphology was performed using proprietary software (Chondrometrics GmbH, Ainring, Germany).Results: The precision error ( root mean square coefficient of variation (RMS CV)%) for cartilage thickness/volume measurements ranged from 2.1%/2.4% (medial tibia) to 2.9%/3.3% ( lateral weight-bearing femoral condyle) across all participants. No significant differences in precision errors were observed between KLGs, imaging sites, or scanner manufacturers/types. Mean differences between baseline and 3 months ranged from