Opioid modulation of social play reward in juvenile rats
Opioid modulation of social play reward in juvenile rats
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DOI：
10.1016/j.neuropharm.2018.09.007
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发表时间：
2019-11-15
影响因子：
4.7
通讯作者：
Vanderschuren, L. J. M. J.
中科院分区：
文献类型：
--
作者：
Achterberg, E. J. M.;van Swieten, M. M. H.;Vanderschuren, L. J. M. J.
社会游戏行为是一种活跃的社会互动形式，广泛存在于许多哺乳动物物种的青少年和青少年阶段，包括老鼠和人类。社交游戏被认为对社交、情感和认知发展具有重要意义。作为一种有益的活动，社交游戏的表现取决于它的愉悦性和激励性。由于阿片类药物广泛涉及奖赏过程，在本研究中，我们研究了阿片类药物在大鼠社交游戏行为的愉悦和动机特性中的作用。为了评估社交游戏动机，我们使用了一种操作条件设置，即大鼠在强化的递进比率时间表下对社交游戏做出反应。阿片受体激动剂吗啡在测试的最高剂量下减少了对社交游戏的反应，可能是由于它的限速作用。在强化阶段，吗啡治疗增加了社交游戏行为的表达。社会游戏诱导的条件性位置偏爱(CPP)的习得可通过吗啡处理得到增强。单用吗啡治疗也可诱发CPP。相反，用纳洛酮拮抗阿片受体可减少对社交游戏的反应，减少社交游戏的表达，并阻断社交游戏诱导的CPP的发展。这些数据表明，阿片类神经传递在大鼠社交游戏行为的愉悦和动机方面都有影响。这篇文章是题为《社会行为的神经药理学：从长凳到床边》的特刊的一部分。
Social play behaviour is a vigorous form of social interaction abundant during the juvenile and adolescent phases of life in many mammalian species, including rats and humans. Social play is thought to be important for social, emotional and cognitive development. Being a rewarding activity, the expression of social play depends on its pleasurable and motivational properties. Since opioids have been widely implicated in reward processes, in the present study we investigated the role of opioids in the pleasurable and motivational properties of social play behaviour in rats. To assess social play motivation, an operant conditioning setup was used in which rats responded for social play under a progressive ratio schedule of reinforcement. Treatment with the opioid receptor agonist morphine reduced responding for social play at the highest dose tested, likely due to its rate-limiting effects. Morphine treatment increased the expression of social play behaviour during reinforced periods. The acquisition of social play-induced conditioned place preference (CPP) in a subeffective conditioning protocol was enhanced by treatment with morphine. Morphine treatment alone also induced CPP. In contrast, antagonizing opioid receptors with naloxone reduced responding for social play, the expression of social play and blocked the development of social play-induced CPP. These data implicate opioid neurotransmission in both the pleasurable and the motivational aspects of social play behaviour in rats.This article is part of the Special Issue entitled 'The neuropharmacology of social behavior: from bench to bedside'.