Are Infertile Men Less Healthy than Fertile Men? Results of a Prospective Case-Control Survey
Are Infertile Men Less Healthy than Fertile Men? Results of a Prospective Case-Control Survey
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DOI：
10.1016/j.eururo.2009.03.001
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发表时间：
2009-12-01
期刊：
影响因子：
23.4
通讯作者：
Montorsi, Francesco
中科院分区：
文献类型：
--
作者：
Salonia, Andrea;Matloob, Rayan;Montorsi, Francesco
背景：生育力低下或不育与某些男性癌症风险升高之间的相关性先前已有报道。没有什么是已知的异常不孕症和一般的健康conditions.Objective：为了评估男性因素不育（MFI）是否整体健康不如生育的男子，无论原因infertiles.Design，设置，和参与者：从2006年9月至2007年9月，344个连续的欧洲白人男性与MFI参加了这项前瞻性病例对照研究。将患者与293名年龄相当的连续生育男性对照组进行比较。不育男性连续参加男性生殖门诊在第三学术中心。生育控制连续招募使用的广告张贴在我们hospital.Measurements：患者和生育男性的合并症进行了客观的评分与Charlson合并症指数（CCI）根据国际疾病分类修订第九版（ICD-9-CM）代码。多变量线性回归模型检验了预测因子与CCI评分之间的关系，CCI评分作为一般健康状况的代表。结果：根据CCI评分，不育男性与生育对照组相比，有显著更高的合并症发生率（CCI：0.33 [0.8] vs 0.14 [0.5]; p < 0.001; 95%CI：0.08-0.29）。线性回归分析显示，尽管教育状况对CCI没有影响（β：0.035; p = 0.365），但CCI随年龄（β：0.196; p < 0.001）和体重指数（BMI; β：0.161; p < 0.001）线性增加。在调整年龄、BMI和教育状况后，计算出生育男性的CCI显著低于MFI患者（β：-0.199; p < 0.001）。结论：这些结果表明，MFI导致CCI较高，这可能被认为是较低总体健康状况的可靠代表。(C)2009年欧洲泌尿外科协会。由Elsevier B出版。版权所有© 2016
Background: An association between either subfertility or infertility and an elevated risk of certain male cancers has been previously reported. Nothing is known about abnormalities in infertility and general health conditions.Objective: To assess whether men with male factor infertility (MFI) are overall less healthy than fertile men, regardless of the reasons for infertility.Design, setting, and participants: From September 2006 to September 2007, 344 consecutive European Caucasian men with MFI were enrolled in this prospective case-controlled study. Patients were compared with a control group of 293 consecutive age-comparable fertile men. Infertile men were consecutively attending the outpatient male reproductive clinic at a tertiary academic center. Fertile controls were consecutively recruited by use of advertisements posted within our hospital.Measurements: Comorbidities of patients and fertile men were objectively scored with the Charlson Comorbidity Index (CCI) according to the International Classification of Diseases modified ninth version (ICD-9-CM) codes. Multivariate linear regression models tested the association between predictors and CCI score, as a proxy of general health status.Results: According to the CCI scores, infertile men had a significantly higher rate of comorbidities compared with the fertile controls (CCI: 0.33 [0.8] vs 0.14 [0.5]; p < 0.001; 95% CI: 0.08-0.29). Linear regression analyses showed that although educational status did not have an impact on CCI (beta: 0.035; p = 0.365), while CCI linearly increased with age (beta: 0.196; p < 0.001) and body mass index (BMI; beta: 0.161; p < 0.001). After adjusting for age, BMI, and educational status, a significantly lower CCI was calculated for fertile men and compared with MFI patients (beta: -0.199; p < 0.001).Conclusions: These results show that MFI accounts for a higher CCI, which may be considered a reliable proxy of a lower general health status. (C) 2009 European Association of Urology. Published by Elsevier B. V. All rights reserved.