The Multiple Regulatory Relationship Between RNA-Chaperone Hfq and the Second Messenger c-di-GMP.
The Multiple Regulatory Relationship Between RNA-Chaperone Hfq and the Second Messenger c-di-GMP.
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RNA伴侣Hfq与第二信使c-di-GMP之间的多重调控关系
DOI：
10.3389/fmicb.2021.689619
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发表时间：
2021
影响因子：
5.2
通讯作者：
He J
中科院分区：
文献类型：
--
作者：
Fu Y;Yu Z;Zhu L;Li Z;Yin W;Shang X;Chou SH;Tan Q;He J
RNA伴侣蛋白Hfq是细菌中重要的转录后调节因子，而c-di-GMP是细菌中广泛分布的第二信使信号分子。这两种因子分别在转录后调控和信号转导途径中起关键作用。有趣的是，这两个因子在调节细菌运动性、生物膜形成、致病性等某些生理功能方面表现出一些共同的方面，因此，Hfq和c-di-GMP之间可能存在调节关系。例如，Hfq可以直接调节c-di-GMP代谢酶的活性或通过其他系统改变c-di-GMP水平，而c-di-GMP可以通过中间因子间接增强或抑制hfq基因表达。本文在简要介绍Hfq和c-di-GMP调控系统的基础上，重点介绍Hfq和c-di-GMP之间的直接调控和间接调控，旨在比较和联系这两种调控系统，进一步研究细菌复杂的生理代谢系统，为绘制更完整的全球调控网络奠定坚实的基础。
RNA chaperone protein Hfq is an important post-transcriptional regulator in bacteria, while c-di-GMP is a second messenger signaling molecule widely distributed in bacteria. Both factors have been found to play key roles in post-transcriptional regulation and signal transduction pathways, respectively. Intriguingly, the two factors show some common aspects in the regulation of certain physiological functions such as bacterial motility, biofilm formation, pathogenicity and so on. Therefore, there may be regulatory relationship between Hfq and c-di-GMP. For example, Hfq can directly regulate the activity of c-di-GMP metabolic enzymes or alter the c-di-GMP level through other systems, while c-di-GMP can indirectly enhance or inhibit the hfq gene expression through intermediate factors. In this article, after briefly introducing the Hfq and c-di-GMP regulatory systems, we will focus on the direct and indirect regulation reported between Hfq and c-di-GMP, aiming to compare and link the two regulatory systems to further study the complicated physiological and metabolic systems of bacteria, and to lay a solid foundation for drawing a more complete global regulatory network.
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3.6
作者：
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