Gestational Hypertension as Risk Factor of Hypertension in Middle-Aged and Older Women
Gestational Hypertension as Risk Factor of Hypertension in Middle-Aged and Older Women
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DOI：
10.3390/ijerph17114052
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发表时间：
2020-06-01
影响因子：
--
通讯作者：
Kobashi, Gen
中科院分区：
文献类型：
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作者：
Watanabe, Mariko;Sairenchi, Toshimi;Kobashi, Gen
在日本女性中，妊娠期高血压(GH)与未来高血压之间的关联尚不清楚。因此，这项研究旨在研究生长激素与日本中老年女性未来高血压风险的关系。病例对照研究包括62例高血压妇女(病例组)和75例非高血压妇女(对照组)。根据《母婴健康手册》的记录诊断第一次妊娠期间的生长激素。高血压妇女是从医院的门诊患者和在社区完成年度健康检查的居民中招募的。高血压的定义是：血压收缩压=140毫米汞柱和/或舒张压=90毫米汞柱，或服用降压药。病例组和对照组招募时的平均年龄分别为63.1岁(8.4岁)和57.7岁(9.4岁)。在调整了招募时的年龄和体重指数(BMI)、孕前体重指数和初产年龄等潜在混杂因素后，中老年妇女生长激素对高血压的多变量调整优势比为4.2(95%可信区间，1.0-17.5)。总而言之，生长激素可能是日本女性未来高血压的独立危险因素。
The association of gestational hypertension (GH) with future hypertension in Japanese women is unclear. Hence, this study aimed to examine the association between GH and the risk of future hypertension in middle-aged-to-older Japanese women. A case-control study was performed, including 62 hypertensive women (case) and 75 nonhypertensive women (control). GH during the first pregnancy was diagnosed on the basis of the Maternal and Child Health Handbook record. Hypertensive women were recruited from outpatients in the hospital and residents who completed an annual health check-up in a community. Hypertension was defined as blood pressure with systolic blood pressure >= 140 mmHg and/or diastolic blood pressure >= 90 mmHg, or taking antihypertensive medications. The average age (SD) of the cases and controls at the time of recruitment was 63.1 (8.4) and 57.7 (9.4), respectively. The multivariable-adjusted odds ratio of GH for hypertension in middle-aged-to-older women was 4.2 (95% confidence interval, 1.0-17.5) after adjustment for potential confounding factors such as age and body-mass index (BMI) upon recruitment, prepregnancy BMI, and age at first delivery. In conclusion, GH can be an independent risk factor for future hypertension among Japanese women.