Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan
Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan
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DOI：
10.1007/s00535-009-0012-3
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发表时间：
2009-03
影响因子：
6.3
通讯作者：
J. Inoue;Y. Ueno;F. Nagasaki;T. Akahane;K. Fukushima;T. Kogure;Y. Kondo;Eiji Kakazu;Keiichi Tamai;Osamu Kido;Y. Nakagome;M. Ninomiya;Noriyuki Obara;Yuta Wakui;Masaharu Takahashi;H. Okamoto;T. Shimosegawa
中科院分区：
文献类型：
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作者：
J. Inoue;Y. Ueno;F. Nagasaki;T. Akahane;K. Fukushima;T. Kogure;Y. Kondo;Eiji Kakazu;Keiichi Tamai;Osamu Kido;Y. Nakagome;M. Ninomiya;Noriyuki Obara;Yuta Wakui;Masaharu Takahashi;H. Okamoto;T. Shimosegawa
最近的研究表明，本土戊型肝炎病毒（HEV）毒株在工业化国家引起戊型肝炎。我们的目的是澄清过去十年日本东北部宫城散发性肝炎患者的HEV感染特征。方法对1999 ~ 2008年间94例非甲、非乙、非丙型急性或重型肝炎患者的血清样本进行分析。检测HEV抗体（抗HEV），检测IgM-和/或iga级抗HEV阳性的患者诊断为戊型肝炎。检测这些患者的HEV RNA，并进行系统发育分析。结果8例（8.5%）急性肝炎患者诊断为戊型肝炎，7例检测到HEV RNA。5株HEV分离株为基因3型，2株分离株为基因4型。从1999年到2008年，戊型肝炎的发病年份几乎均匀分布，而急性甲型肝炎的病例（16例）在过去几年中显著减少。2004-2008年，戊型肝炎的发病率高于甲型肝炎（5例对1例）。就季节性而言，戊型肝炎在9月至12月的发病率高于甲型肝炎（5例对4例），但在1月至4月的发病率较低（1例对7例）。结论近十年来，日本东北地区戊型肝炎的发病率与甲型肝炎相比并没有下降。
BackgroundRecent studies have shown that indigenous hepatitis E virus (HEV) strains cause hepatitis E in industrialized countries. We aimed to clarify the characteristics of HEV infection in sporadic hepatitis patients during the last decade in Miyagi, northeast Japan.MethodsWe analyzed 94 serum samples obtained from acute or fulminant hepatitis patients of non-A, non-B, and non-C etiology between 1999 and 2008. Antibody to HEV (anti-HEV) was assayed, and patients who were positive for IgM- and/or IgA-class anti-HEV were diagnosed with hepatitis E. HEV RNA was tested in these patients, and phylogenetic analysis was performed. The occurrence of hepatitis E was compared with that of hepatitis A.ResultsEight acute hepatitis patients (8.5%) were diagnosed with hepatitis E, and HEV RNA was detectable in seven patients. Five isolates of HEV were segregated into genotype 3 and the remaining two isolates into genotype 4. The year of the occurrence of hepatitis E was distributed almost equally from 1999 to 2008, whereas the cases of acute hepatitis A (n= 16) have decreased markedly in the last several years. In 2004–2008, the occurrence of hepatitis E was greater than that of hepatitis A (five cases vs. one case). As for seasonality, hepatitis E occurred more frequently from September to December than hepatitis A (five cases vs. four cases), although less frequently from January to April (one case vs. seven cases).ConclusionThe occurrence of hepatitis E has not decreased during the last decade in northeast Japan, in contrast to hepatitis A.