Cellular Nanosponges for Biological Neutralization
Cellular Nanosponges for Biological Neutralization
复制标题
用于生物中和的细胞纳米海绵
DOI：
10.1002/adma.202107719
复制
发表时间：
2022
影响因子：
29.4
通讯作者：
Zhang, Liangfang
中科院分区：
文献类型：
--
作者：
Wang, Shuyan;Wang, Dan;Duan, Yaou;Zhou, Zhidong;Gao, Weiwei;Zhang, Liangfang
生物中和是一种利用治疗药物与有害分子或感染性病原体结合，阻断其生物活性，从而防止其引起疾病的一般策略。在这里，使用细胞膜包被的纳米粒子，即“细胞纳米海绵”，作为主机诱饵广泛的生物中和应用提供了一个全面的审查。与传统的中和策略相比，细胞纳米海绵通过模仿易感宿主细胞而不是适应病原体的结构来设计治疗剂而脱颖而出。由于所有的病理因子必须与宿主细胞相互作用以获得生物活性，纳米海绵绕过了这些因子的多样性，并创造了功能驱动和广谱的中和解决方案。本文综述了利用这种新的纳米医学平台对细菌毒素、化学毒物、炎症细胞因子、病理抗体和病毒等5种主要病理因子进行中和的最新进展。现有的研究已经建立了细胞纳米海绵作为生物中和的通用工具。对细胞纳米海绵技术的全面审查有望激发更精细的细胞纳米海绵设计和独特的中和应用，以解决未解决的医疗问题。
Biological neutralization represents a general strategy that deploys therapeutic agents to bind with harmful molecules or infectious pathogens, block their bioactivity, and thus prevent them from causing the diseases. Here, a comprehensive review of using cell‐membrane‐coated nanoparticles, namely “cellular nanosponges,” as host decoys for a wide range of biological neutralization applications is provided. Compared to traditional neutralization strategies, the cellular nanosponges stand out by mimicking susceptible host cells rather than accommodating the structures of the causative agents for the design of therapeutics. As all pathological agents must interact with host cells for bioactivity, nanosponges bypass the diversity of these agents and create function‐driven and broad‐spectrum neutralization solutions. The review focuses on the recent progress of using this new nanomedicine platform for neutralization against five primary pathological agents, including bacterial toxins, chemical toxicants, inflammatory cytokines, pathological antibodies, and viruses. Existing studies have established cellular nanosponges as versatile tools for biological neutralization. A thorough review of the cellular nanosponge technology is expected to inspire more refined cellular nanosponge designs and unique neutralization applications to address unsolved medical problems.