Nanomedicine Fabricated from A Boron-dipyrromethene (BODIPY)-Embedded Amphiphilic Copolymer for Photothermal-Enhanced Chemotherapy
Nanomedicine Fabricated from A Boron-dipyrromethene (BODIPY)-Embedded Amphiphilic Copolymer for Photothermal-Enhanced Chemotherapy
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由硼二吡咯亚甲基 (BODIPY) 嵌入的两亲性共聚物制成的纳米药物，用于光热增强化疗
DOI：
10.1021/acsbiomaterials.9b01145
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发表时间：
2019
影响因子：
--
通讯作者：
Chen Xiaoyuan
中科院分区：
文献类型：
--
作者：
Shen Jie;Wang Qiwen;Lv Yuanyuan;Dong Jingyin;Xuan Guida;Yang Jie;Wu Dan;Zhou Jiong;Yu Guocan;Tang Guping;Li Xiao;Huang Feihe;Chen Xiaoyuan
为了克服化疗的缺点，包括副作用和不可控制的释放，以及增加治疗效果，构建了含有近红外吸收的硼-二吡咯亚甲基（BODIPY）尾部、疏水性聚乳酸（PLA）片段和亲水性聚（乙二醇）（PEG）片段的二嵌段共聚物（mPEG-b-PLA-BODIPY）。利用mPEG-b-PLA-BODIPY自组装的核-壳结构纳米粒通过疏水作用将多西他赛（DTX）负载于核中。充分利用光热效应和增强的渗透滞留效应，实现了纳米药物的定制化释药和高肿瘤穿透性，提高了治疗效果，降低了不良反应。体内抗肿瘤研究表明，光热增强化疗有效抑制肿瘤进展，而合理的设计可显著降低DTX的全身毒副作用。这个开创性的例子提供了一个蓝图，为下一代的聚合物输送车辆集成新的治疗诊断功能。
To overcome the shortcomings of chemotherapy including side effects and uncontrollable release, as well as to increase the therapeutic efficacy, a diblock copolymer (mPEG-b-PLA-BODIPY) was constructed containing a NIR absorbing boron-dipyrromethene (BODIPY) tail, a hydrophobic polylactide (PLA) segment, and a hydrophilic poly(ethylene glycol) (PEG) segment. The nanoparticles self-assembled from mPEG-b-PLA-BODIPY with a core–shell structure were utilized to load docetaxel (DTX) in the core through hydrophobic interaction. Tailored drug release and high tumor penetration of the nanomedicine were realized by fully taking advantage of photothermal effect and the enhanced penetration and retention effect, facilitating enhanced therapeutic performance and reducing undesirable side effects.In vivoantitumor studies demonstrate that photothermal-enhanced chemotherapy effectively suppresses tumor progression, while systemic toxicity and side effects of DTX are remarkably decreased benefiting from rational design. This pioneering example provides a blueprint for the next generation of polymeric delivery vehicles integrating novel theranostic functions.