Combination HIV prevention: the value and interpretation of mathematical models.
Combination HIV prevention: the value and interpretation of mathematical models.
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艾滋病毒联合预防：数学模型的价值和解释。
DOI：
10.1007/s11904-013-0167-7
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发表时间：
2013
影响因子：
4.6
通讯作者：
Walensky,RochelleP
中科院分区：
文献类型：
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作者：
Walensky,RochelleP
艾滋病毒预防干预措施的数学模型通常提供与方案设计和经济效率相关的关键见解。Long等人最近的一个动态模型强调，结合检测、治疗、包皮环切、杀微生物剂和预防措施的综合预防方法可使传播减少60%以上，在南非可能非常具有成本效益。在本分析中，作者介绍了预防方案联合有效性的关键概念，并展示了一些方案如何协同运作（艾滋病毒筛查与早期治疗相结合），而其他方案可能会产生冗余（杀菌剂与暴露前预防相结合）。综合艾滋病毒预防规划的效果是否具有相加性、乘法性或最大有效性，在预测其综合传播影响时将是重要的考虑因素。
Mathematical models of HIV prevention interventions often provide critical insights related to programmatic design and economic efficiency. One recent dynamic model by Long et al. highlights that a combination prevention approach – with testing, treatment, circumcision, microbicides and PrEP – may decrease transmissions by over 60 % and may be very cost-effective in South Africa. In this analysis, the authors introduce the critical concept of joint effectiveness of preventions programs and demonstrate how some programs operate synergistically (HIV screening coupled with early treatment) while others may create redundancies (microbicides coupled with pre-exposure prophylaxis). Whether combination HIV prevention programs perform with additive, multiplicative or maximal effectiveness will be important to consider in anticipation of their combined transmission impact.