Macrophage Clearance of Apoptotic Cells: A Critical Assessment.
Macrophage Clearance of Apoptotic Cells: A Critical Assessment.
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DOI：
10.3389/fimmu.2018.00127
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发表时间：
2018
影响因子：
7.3
通讯作者：
Plüddemann A
中科院分区：
文献类型：
--
作者：
Gordon S;Plüddemann A
随着身体的不断生长和衰老，维持活细胞和死细胞之间的平衡变得至关重要。巨噬细胞和树突状细胞作为选择性和高效的吞噬细胞，在区分活细胞、凋亡细胞和坏死细胞方面发挥着核心作用，而不会引起不适当的炎症或免疫反应。关于清除修饰和非自配体在潜在靶标上的受体，介导它们的最终摄取、处置和替换，我们已经了解了很多。在这篇文章中，我们评估了目前对凋亡细胞在其组织环境中的吞噬识别的理解；我们的结论是，efferocytosis构成了一个比简单清除尸体更复杂的过程，目标细胞和效应细胞之间的调节相互作用决定了这一稳态过程的结果。
As the body continues to grow and age, it becomes essential to maintain a balance between living and dying cells. Macrophages and dendritic cells play a central role in discriminating among viable, apoptotic, and necrotic cells, as selective and efficient phagocytes, without inducing inappropriate inflammation or immune responses. A great deal has been learnt concerning clearance receptors for modified and non-self-ligands on potential targets, mediating their eventual uptake, disposal, and replacement. In this essay, we assess current understanding of the phagocytic recognition of apoptotic cells within their tissue environment; we conclude that efferocytosis constitutes a more complex process than simply removal of corpses, with regulatory interactions between the target and effector cells, which determine the outcome of this homeostatic process.