Diosgenin exerts an antihypertensive effect in spontaneously hypertensive rats via gut-brain communication
Diosgenin exerts an antihypertensive effect in spontaneously hypertensive rats via gut-brain communication
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薯蓣皂苷元通过肠脑通讯对自发性高血压大鼠发挥抗高血压作用
DOI：
10.1039/d2fo00946c
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发表时间：
2022
期刊：
影响因子：
6.1
通讯作者：
Hongli Jiang
中科院分区：
文献类型：
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作者：
Meng-Lu Xu;Bo Peng;Juan Bai;Lu Li;Yan Du;Zhi-Qiang Wang;Sha-Sha Li;Xiao-Xi Liu;Yuan-Yuan Dong;Jun-Zhe Wu;Ling-Xiao Xiong;Lei Chen;Hong-Bao Li;Hongli Jiang
肠道微生物群是公认的调节宿主血压。薯蓣皂苷元是一种天然的甾体皂苷元，具有抗炎、抗氧化和抗高血压的特性。本研究旨在探讨薯蓣皂苷元对自发性高血压大鼠（SHR）的降压作用是否通过微生物群-肠-脑轴介导。将15周龄雄性Wistar京都大鼠（WKY）和年龄匹配的SHR随机分为三组：WKY组、溶媒处理的SHR组和薯蓣皂苷元（100 mg kg-1）处理的SHR组。我们的研究结果表明，薯蓣皂苷元预防收缩压（SBP）升高，并改善SHR的心肌肥厚。此外，肠道微生物群组成和肠道完整性得到改善。薯蓣皂苷元还能增加SHR的丁酸菌群和血浆丁酸水平，降低血浆脂多糖水平。这些发现与室旁核中小胶质细胞活化减少和神经炎症有关。我们的研究结果表明，薯蓣皂苷元通过重塑肠道微生物群和改善肠-脑轴来减轻高血压。
Gut microbiota is well-established to regulate host blood pressure. Diosgenin is a natural steroid sapogenin with documented anti-inflammatory, antioxidant and antihypertensive properties. We aimed to investigate whether the antihypertensive effects of diosgenin are mediated by the microbiota-gut-brain axis in spontaneously hypertensive rats (SHR). 15-Week-old male Wistar Kyoto rats (WKY) and age-matched SHR were randomly distributed into three groups: WKY, SHR treated with a vehicle, and SHR treated with diosgenin (100 mg kg-1). Our results showed that diosgenin prevented elevated systolic blood pressure (SBP) and ameliorated cardiac hypertrophy in SHR. Moreover, the gut microbiota composition and intestinal integrity were improved. Furthermore, increased butyrate-producing bacteria and plasma butyrate and decreased plasma lipopolysaccharides were observed in SHR treated with diosgenin. These findings were associated with reduced microglial activation and neuroinflammation in the paraventricular nucleus. Our findings suggest that diosgenin attenuates hypertension by reshaping the gut microbiota and improving the gut-brain axis.