Genome diversification mechanism of rodent and Lagomorpha chemokine genes.
Genome diversification mechanism of rodent and Lagomorpha chemokine genes.
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DOI：
10.1155/2013/856265
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发表时间：
2013
影响因子：
--
通讯作者：
Tanase S
中科院分区：
文献类型：
--
作者：
Shibata K;Nomiyama H;Yoshie O;Tanase S
趋化因子是一大类小分子细胞因子，通过募集表达其受体的细胞参与宿主防御和体内动态平衡。众所周知，他们的基因经历了快速的进化。因此，趋化因子基因的数量和含量在不同物种之间可能相当不同，这使得即使在关系密切的物种之间，同源关系也往往是模棱两可的。鉴于啮齿动物和兔是医学和药物开发中有用的实验模型，我们从几种啮齿动物和兔的基因组序列中推导出趋化因子基因，并将其与人和小鼠的基因进行比较，以确定其同源关系。在将动物模型的实验结果外推到人类身上时，应该考虑到物种间的差异。本文提供的趋化因子基因列表及其同源关系将有助于使用这些动物模型进行研究。我们的分析还使我们能够重建可能的基因复制过程，这些过程在这些物种中产生了不同的趋化因子基因。
Chemokines are a large family of small cytokines that are involved in host defence and body homeostasis through recruitment of cells expressing their receptors. Their genes are known to undergo rapid evolution. Therefore, the number and content of chemokine genes can be quite diverse among the different species, making the orthologous relationships often ambiguous even between closely related species. Given that rodents and rabbit are useful experimental models in medicine and drug development, we have deduced the chemokine genes from the genome sequences of several rodent species and rabbit and compared them with those of human and mouse to determine the orthologous relationships. The interspecies differences should be taken into consideration when experimental results from animal models are extrapolated into humans. The chemokine gene lists and their orthologous relationships presented here will be useful for studies using these animal models. Our analysis also enables us to reconstruct possible gene duplication processes that generated the different sets of chemokine genes in these species.
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影响因子：
56.9
作者：
Gonzalez, E;Kulkarni, H;Ahuja, SK
通讯作者：
Ahuja, SK
影响因子：
5
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Nomiyama, H;Mera, A;Yoshie, O
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通讯作者：
Bustamante CD