Does methylphenidate improve inhibition and other cognitive abilities in adults with childhood-onset ADHD?
Does methylphenidate improve inhibition and other cognitive abilities in adults with childhood-onset ADHD?
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DOI：
10.1080/13803390490515757
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发表时间：
2005-04-01
影响因子：
2.2
通讯作者：
Buitelaar, JK
中科院分区：
文献类型：
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作者：
Boonstra, AM;Kooij, JSS;Buitelaar, JK
我们通过Conners' Continuous Performance Test （CPT）和Change Task (ChT)（停止信号测试（SST）的延伸）研究了哌醋甲酯（Mph）对43名注意缺陷多动障碍（ADHD）成人的抑制和其他几种认知能力的影响。在一项双盲、交叉、安慰剂对照研究中，在Mph单独滴定治疗的第三周（最大剂量为1mg /kg /天）和安慰剂治疗的第三周进行了试验。我们确定了在CPT上的委托误差、平均反应时间标准误差和注意力有较大的药物效应，而在CPT上的平均反应时间和在ChT上的反应再投入速度有中等的药物效应。对于ChT的停止信号反应时间（SSRT），我们也确定了Mph的巨大影响，但仅在安慰剂组显示缓慢SSRT的参与者中。Mph确实改善了抑制，这是ADHD的核心问题，以及ADHD成人的某些其他认知能力。
We examined the effect of methylphenidate (Mph) on inhibition and several other cognitive abilities in 43 adults with Attention Deficit Hyperactivity Disorder (ADHD) by use of Conners' Continuous Performance Test (CPT) and the Change Task (ChT), an extension of the Stop Signal Test (SST). In a double blind, cross-over, placebo controlled study with Mph, tests were administered during the third week of individually titrated treatment with Mph (maximum dose 1 mg/kg /day) and during the third week of treatment with placebo. We established large medication effects for commission errors, standard error of mean reaction time, and attentiveness on the CPT, as well as moderate medication effects for mean reaction time on the CPT and response re-engagement speed on the ChT. For Stop Signal Reaction Time (SSRT) on the ChT, we also established large effects of Mph, but only, in a group of participants who showed slow SSRTs on placebo. Mph indeed ameliorates inhibition, which is the core problem of ADHD, and certain other cognitive abilities in adults with ADHD.