Regional and fiber orientation dependent shear properties and anisotropy of bovine meniscus.
Regional and fiber orientation dependent shear properties and anisotropy of bovine meniscus.
复制标题
DOI：
10.1016/j.jmbbm.2011.06.022
复制
发表时间：
2011-11
影响因子：
3.9
通讯作者：
Donahue, Tammy L. Haut
中科院分区：
文献类型：
--
作者：
Abraham, Adam C.;Edwards, Christian R.;Odegard, Gregory M.;Donahue, Tammy L. Haut
椎间盘组织的成像显示细胞外基质由排列在周向束中的胶原纤维和径向排列的系纤维组成，暗示结构材料的各向异性。生化分析表明，蛋白多糖含量的区域差异，整个椎间盘体，一个成分，已知影响纤维软骨组织的剪切反应。尽管有这种现象学证据和先前的机械测试暗示，但半月板通常被建模为均匀的横向各向同性材料，很少考虑区域特异性和材料特性。本研究的目的是确定牛髂内和之间在解剖位置（内侧和外侧）、区域（前部、中部和后部）和纤维方向（平行和垂直）方面是否存在剪应力反应均匀性和方向性。半月板外植体以0.002 sec-1的速度承受搭接剪切应变，周围胶原纤维平行或垂直于加载轴。使用分段线性弹性分析进行了比较。从3%-13%应变之间的第一个观察到的线性区域计算趾部区域剪切模量，并且在最大剪切应变的80%之后建立扩展剪切模量。后部区域的扩展剪切模量与中心区域显著不同，与已知的蛋白多糖分布相关。所观察到的剪切各向异性导致使用的各向异性超弹性模型的基础上的两个纤维的家庭复合材料，以前用于动脉壁。选定的模型非常适合每个区域的样本群体。这些数据可用于有限元建模以及仿生组织工程构建的进步。
Imaging of meniscal tissue reveals an extracellular matrix comprised of collagen fibrils arranged in circumferential bundles and radially aligned tie fibers, implicating structural material anisotropy. Biochemical analyses demonstrate regional disparities of proteoglycan content throughout the meniscal body, a constituent known to affect the shearing response of fibrocartilagenous tissue. Despite this phenomenological evidence and previous mechanical testing implicating otherwise, the meniscus if often modeled as a homogenous, transversely isotropic material with little regard for regional specificity and material properties. The aim of this investigation was to determine if shear stress response homogeneity and directionality exists in and between bovine menisci with respect to anatomical location (medial and lateral), region (anterior, central, and posterior) and fiber orientation (parallel and perpendicular). Meniscus explants were subjected to lap shear strain at 0.002 sec−1 with the circumferential collagen fibers oriented parallel or perpendicular to the loading axis. Comparisons were made using a piecewise linear elastic analysis. The toe region shear modulus was calculated from the first observed linear region, between 3%-13% strain and the extended shear modulus was established after 80% of the maximum shear strain. The posterior region was significantly different than the central for the extended shear modulus, correlating with known proteoglycan distribution. Observed shearing anisotropy led to the use of an anisoptropic hyperelastic model based on a two-fiber family composite, previously used for arterial walls. The chosen model provided an excellent fit to the sample population for each region. These data can be utilized in the advancement of finite element modeling as well as biomimetic tissue engineered constructs.
登录
查看更多内容
影响因子：
2.8
作者：
ANDERSON, DR;WOO, SLY;GERSHUNI, DH
通讯作者：
GERSHUNI, DH
DOI：
10.1115/1.3138409
发表时间：
1983-01-01
影响因子：
1.7
作者：
AHMED, AM;BURKE, DL
通讯作者：
BURKE, DL
DOI：
10.1243/0954411001535651
发表时间：
2000-01-01
影响因子：
1.8
作者：
Leslie, BW;Gardner, DL;Moran, RS
通讯作者：
Moran, RS
影响因子：
2
作者：
Holzapfel, GA;Gasser, TC;Ogden, RW
通讯作者：
Ogden, RW
影响因子：
2.8
作者：
PROCTOR, CS;SCHMIDT, MB;MOW, VC
通讯作者：
MOW, VC