Concomitants of Atherosclerotic Carotid Artery Stenosis
Concomitants of Atherosclerotic Carotid Artery Stenosis
复制标题
动脉粥样硬化性颈动脉狭窄的并发症
作者：
G. Duncan;R. Lees;R. Ojemann;S. David
为了确定一种重要的动脉粥样硬化性脑血管疾病的代谢和其他并发症，我们将75例经血管造影和手术证实的颈内动脉狭窄患者与年龄和性别匹配的对照组进行了血浆胆固醇、甘油三酯和葡萄糖的比较。他们还比较了血压、吸烟、缺血性心脏病、周围血管疾病的证据以及这些疾病的家族史。颈动脉狭窄患者的收缩压和舒张压高于对照组，血浆胆固醇和甘油三酯浓度也高于对照组。同时，他们吸烟的可能性更大，患糖尿病的可能性更大，之前有冠状动脉和周围血管疾病的证据。颈动脉狭窄的患者比对照组更有可能有2种或更多常见的动脉粥样硬化伴随症状。这些数据表明，颈动脉狭窄的前体与冠状动脉粥样硬化的前体相似，并提出了改变这些因素可能降低这种高度流行的脑血管疾病发病率的希望。
To identify metabolic and other concomitants of a single important type of atherosclerotic cerebrovascular disease, 75 patients with angiographically and surgically proven internal carotid stenosis were compared with age and sex matched control subjects with respect to plasma cholesterol, triglycerides and glucose. They were also compared for blood pressure, cigarette smoking, evidence of ischemic heart disease, peripheral vascular disease and for a family history of these diseases. Patients with carotid stenosis had higher systolic and diastolic blood pressures and higher plasma cholesterol and triglyceride concentrations than the control groups. They had, as well, a far greater likelihood of being cigarette smokers and a greater likelihood of having diabetes mellitus and previous evidence of coronary and peripheral vascular disease. Patients with carotid stenosis were far more likely to have 2 or more of these common concomitants of atherosclerosis than were the control subjects. The data suggest that the precursors of carotid stenosis are similar to those of coronary atherosclerosis and raise the hope that modification of these factors may decrease the incidence of this highly prevalent form of cerebrovascular disease.