Evidence for dopaminergic control of circadian variations in thyrotropin secretion.
Evidence for dopaminergic control of circadian variations in thyrotropin secretion.
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多巴胺能控制促甲状腺素分泌昼夜节律变化的证据。
DOI：
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发表时间：
1982
影响因子：
5.8
通讯作者：
J. Hershman
中科院分区：
文献类型：
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作者：
J. Sowers;R. Catania;J. Hershman
本研究探讨多巴胺对卧位血浆TSH昼夜分泌模式的影响。在对照组（无药物治疗）和溴隐亭治疗组（2.5 mg溴隐亭，每天三次，持续5天）期间，对7名甲状腺功能正常的男性进行了研究。在对照期，血浆TSH有明显的每日模式，最高水平出现在晚睡前和夜间睡眠开始后的前几个小时。在控制期间，卧位24小时血浆TSH与时钟时间呈线性相关（γ = 0.41; P <0.05）。溴隐亭使平均24小时TSH从对照水平2.1 +/- 0.2降至1.1微单位/ml。此外，溴隐亭消除了早期夜间TSH峰和血浆TSH与时钟时间的相关性。因此，血浆TSH水平的昼夜变化可能部分地通过多巴胺能机制来调节。然而，我们不能排除溴隐亭对垂体前叶的直接影响，导致血浆TSH的夜间升高降低。
This study examines the influence of dopamine of recumbent circadian secretory patterns of plasma TSH. Seven euthyroid men were studied during a control (no medication) and a bromocriptine period (2.5 mg bromocriptine three times a day for 5 days). In the control period, a clear daily pattern in plasma TSH was evidenced, with highest levels occurring during the late evening presleep period and the fist few hours after the onset of nocturnal sleep. During the control period, recumbent 24-h plasma TSH was linearly correlated (gamma = 0.41; P less than 0.05) with clock time. Bromocriptine lowered the mean 24-h TSH from a control level of 2.1 +/- 0.2 to 1.1 microunits/ml. Further, bromocriptine eliminated the early nocturnal TSH surge and the correlation of plasma TSH with clock time. Thus, circadian variations in plasma TSH levels may be modulated, in part, by a dopaminergic mechanism. However, we cannot rule out a direct effect of bromocriptine on the anterior pituitary resulting in decreased late evening rises in plasma TSH.
延长多巴胺输注对正常男性垂体前叶功能的影响。
DOI：
10.1210/jcem-51-3-488
发表时间：
1980
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Kaptein,EM;Kletzky,OA;Spencer,CA;Nicoloff,JT
通讯作者：
Nicoloff,JT