From macrocycle dipeptide lactams to azabicyclo[X.Y.0]alkanone amino acids: a transannular cyclization route for peptide mimic synthesis.
From macrocycle dipeptide lactams to azabicyclo[X.Y.0]alkanone amino acids: a transannular cyclization route for peptide mimic synthesis.
复制标题
从大环二肽内酰胺到氮杂双环[X.Y.0]烷酮氨基酸：模拟肽合成的跨环环化途径。
作者：
Simon Surprenant;W. Lubell
[反应：见正文]大环和稠合双环二肽是模拟不同类型β-转角几何形状的互补基序。大环二肽模拟物已经用作合成其双环对应物的前体，其使用9-和10-元环内酰胺9-12的亲电跨环环化以形成氮杂双环[4.3.0]-和-[5.3.0]烷酮氨基酯13-16。
[reaction: see text] Macrocyclic and fused bicyclic dipeptides are complementary motifs for mimicry of different types of beta-turn geometry. Macrocyclic dipeptide mimics have served as precursors for the synthesis of their bicyclic counterparts using electrophilic transannular cyclizations of 9- and 10-membered ring lactams 9-12 to form azabicyclo[4.3.0]- and -[5.3.0]alkanone amino esters 13-16.