Computational biology: Turing's lessons in simplicity
Computational biology: Turing's lessons in simplicity
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DOI：
10.1016/j.bpj.2021.08.041
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发表时间：
2021-10-05
影响因子：
3.4
通讯作者：
Green, Jeremy B. A.
中科院分区：
文献类型：
--
作者：
Green, Jeremy B. A.
发育的生物物理模型始于艾伦·图灵。他的双形态基反应扩散模型是一个激进但有力的简化。尽管有明显的局限性，该模型捕捉到了真实的发育过程，直到最近才在许多系统的分子水平上得到验证。尽管依赖于边界条件，反应扩散模式的精确性和鲁棒性仍然是发育生物学研究的活跃领域。
Biophysical modeling of development started with Alan Turing. His two-morphogen reaction-diffusion model was a radical but powerful simplification. Despite its apparent limitations, the model captured real developmental processes that only recently have been validated at the molecular level in many systems. The precision and robustness of reaction-diffusion patterning, despite boundary condition-dependence, remain active areas of investigation in developmental biology.