REGULATION OF INTRARENAL AND CIRCULATING RENIN-ANGIOTENSIN SYSTEMS IN SEVERE HEART-FAILURE IN THE RAT
REGULATION OF INTRARENAL AND CIRCULATING RENIN-ANGIOTENSIN SYSTEMS IN SEVERE HEART-FAILURE IN THE RAT
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DOI：
10.1093/cvr/27.5.731
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发表时间：
1993-05-01
影响因子：
10.8
通讯作者：
INGELFINGER, JR
中科院分区：
文献类型：
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作者：
SCHUNKERT, H;TANG, SS;INGELFINGER, JR
目的：肾内肾素-血管紧张素系统的激活可能通过加速肾脏局部血管紧张素II的生成而参与心力衰竭的病理生理过程。局部肾素-血管紧张素系统的激活发生在患有轻度心力衰竭的大鼠身上。本研究的目的是检测严重心力衰竭大鼠的循环和肾内肾素-血管紧张素系统的成分。方法：对实验性心肌梗死(心力衰竭，n=8)和假手术(对照组，n=6)后6周的血流动力学和肾素-血管紧张素系统的循环和肾内成分进行研究。结果：心力衰竭大鼠心肌梗死面积较大(瘢痕组织占左心室周长的40%)。与假手术对照组相比，大面积心肌梗死导致严重心力衰竭，收缩压降低[108(SEM3)mm Hgv 132(3)in C；p
Objective: Activation of the intrarenal renin-angiotensin system may contribute to the pathophysiology of heart failure by accelerating the generation of angiotensin II at local sites within the kidneys. Activation of the local intrarenal renin-angiotensin system occurs in rats and with mild heart failure. The aim of the present study was to examine components of the circulating as well as the intrarenal renin-angiotensin system in rats with severe heart failure. Methods: Six weeks after experimental myocardial infarction (heart failure, HF; n=8) or sham operation (control, C; n=6), haemodynamics and the circulating and intrarenal components of the renin-angiotensin system were studied. Results: HF rats were characterised by large infarctions (scar tissue >40% of the left ventricular circumference). In comparison to sham operated controls, large myocardial infarctions resulted in severe heart failure with decreased systolic [108(SEM 3) mm Hg v 132(3) in C; p