Progress in research on the role of amino acid metabolic reprogramming in tumour therapy: A review.
Progress in research on the role of amino acid metabolic reprogramming in tumour therapy: A review.
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DOI：
10.1016/j.biopha.2022.113923
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发表时间：
2022-12
期刊：
影响因子：
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通讯作者：
Dong Wang;Xin Wan
中科院分区：
文献类型：
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作者：
Dong Wang;Xin Wan
恶性肿瘤是影响人类生命健康和生活质量的非传染性疾病。抗肿瘤相关研究也一直是肿瘤学研究的重点和难点。随着代谢组学、肿瘤生物学和肿瘤重编程理论的兴起，氨基酸代谢重编程已成为抗肿瘤研究的新靶点。氨基酸为肿瘤细胞增殖、侵袭和免疫逃逸过程提供了生物分子如核苷酸。它们也是肿瘤微环境中免疫细胞活化和抗肿瘤作用的必需代谢物。氨基酸代谢的异常变化与肿瘤的发生、免疫密切相关。某些必需蛋白质或其代谢途径中的关键酶可作为肿瘤诊断和预后评估的标志物。本文综述了氨基酸代谢对肿瘤细胞增殖的影响以及肿瘤代谢周期中氨基酸代谢的异常变化，并对以氨基酸代谢为靶点的肿瘤治疗药物进行了分析和展望。本文为深入研究氨基酸代谢对肿瘤发生发展的调控及其可能的治疗靶点提供了理论参考。
Malignant tumors are non-communicable diseases that affect human life health and quality of life. Anti-tumour-related research has also been the focus and difficulty in oncology research. With the rise of metabolomics, tumour biology, and the theory of tumour reprogramming, amino acid metabolic reprogramming has become a new target for antitumor research. Amino acids provide biomolecules such as nucleotides for tumour cell proliferation, invasion, and immune escape processes. They are also essential metabolites for immune cell activation and antitumor effects in the tumour microenvironment. Abnormal changes in amino acid metabolism are closely related to tumour development and immunity. Some essential proteins or critical enzymes in their metabolic pathways can be used for tumour diagnosis and prognosis assessment markers. Therefore, this paper reviews the effects of amino acid metabolism on tumour cell proliferation and the abnormal alterations of amino acid metabolism during the tumour metabolic cycle and analyzes and prospects the tumour therapeutic drugs targeting amino acid metabolism. This paper provides theoretical references for the in-depth study of the regulation of amino acid metabolism on tumour development and its possible therapeutic targets.