Unidirectional, electrotactic-response valve for Caenorhabditis elegans in microfluidic devices
Unidirectional, electrotactic-response valve for Caenorhabditis elegans in microfluidic devices
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DOI：
10.1063/1.3570629
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发表时间：
2011-04-04
影响因子：
4
通讯作者：
Pandey, Santosh
中科院分区：
文献类型：
--
作者：
Carr, John A.;Lycke, Roy;Pandey, Santosh
本文报道了一种控制秀丽隐杆线虫（Caelophabditis elegans，C. elegans）中。这种非机械的单向阀基于创建可切换和可逆的横向电场的受限区域。我们观察到C.如果磁力线与其向前运动相关联，那么秀丽线虫不喜欢通过这个区域。在到达NERV的边界时，入射蠕虫部分地穿透场区域，拉回并转向。NERV在三个C上进行了测试。线虫突变体：野生型（N2）、lev-8和acr-16。(C)2011年美国物理学会。[doi：10.1063/1.3570629]
We report a nematode electrotactic-response valve (NERV) to control the locomotion of Caenorhabditis elegans (C. elegans) in microfluidic devices. This nonmechanical, unidirectional valve is based on creating a confined region of lateral electric field that is switchable and reversible. We observed that C. elegans do not prefer to pass through this region if the field lines are incident to its forward movement. Upon reaching the boundary of the NERV, the incident worms partially penetrate the field region, pull back, and turn around. The NERV is tested on three C. elegans mutants: wild-type (N2), lev-8, and acr-16. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3570629]