Molecular and cellular evidence for an oligodendrocyte abnormality in schizophrenia
Molecular and cellular evidence for an oligodendrocyte abnormality in schizophrenia
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DOI：
10.1023/a:1020981510759
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发表时间：
2002-10-01
影响因子：
4.4
通讯作者：
Buxbaum, JD
中科院分区：
文献类型：
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作者：
Hof, PR;Haroutunian, V;Buxbaum, JD
我们以前的分析表明，在疾病状态下，髓鞘和少突胶质细胞相关基因的表达减少，这些样本来自一个特征明确的严重精神分裂症患者队列和匹配的对照组。这种表达减少，现在在独立的研究中重复，表明精神分裂症中少突胶质细胞功能中断和/或少突胶质细胞丢失。在目前的报告中，我们回顾了在精神分裂症的表达研究，目前的数据表明，精神分裂症患者少突胶质细胞始终比对照组少。密度下降达22%（p
Our previous analyses in postmortem prefrontal cortex samples from a well-characterized cohort of severely affected schizophrenics and in matched controls demonstrated decreased expression of myelin and oligodendrocyte-related genes in the disease state. This decreased expression, now replicated in independent studies, suggests that there is a disruption of oligodendrocyte function and/or a loss of oligodendrocytes in schizophrenia. In the current report, we review expression studies in schizophrenia and present data demonstrating consistently fewer oligodendrocytes in schizophrenics compared to controls. The decrease in density reached 22% (p