The effects of oestradiol administration on blood pressure and erythrocyte Na+ influx in oophorectomized rats.
The effects of oestradiol administration on blood pressure and erythrocyte Na+ influx in oophorectomized rats.
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雌二醇给药对卵巢切除大鼠血压和红细胞Na流入的影响。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
G. Stokes
中科院分区：
文献类型：
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作者：
C. Flemming;J. Marwood;G. Stokes
在接受苯甲酸雌二醇（100ug/kg/周，肌肉注射）或载体治疗八周的卵巢切除大鼠中，测量雌激素对血压和红细胞Na+流入的影响。与载体治疗组相比，雌二醇治疗组的平均血压显着升高，同时红细胞[Na+]显着增加。雌二醇给药对总 Na+ 流入、共转运、反转运或 Na+ 扩散没有产生显着变化，并且不会改变血浆 [Na+]、红细胞 [K+]、平均红细胞血红蛋白浓度 (MCHC) 或每 100g 体重的血容量。然而，在雌二醇治疗组中观察到体重、血细胞比容和血浆 [K+] 显着下降。这些结果支持了先前的观察结果，即雌二醇会增加血压，并表明长期服用雌激素会增加红细胞[Na+]，可能是通过改变红细胞被动Na+转运以外的机制。
The effects of oestrogen on blood pressure and erythrocyte Na+ influx were measured in oophorectomized rats treated with oestradiol benzoate (100ug/kg/week i.m.) or vehicle for eight weeks. A significant increase in mean blood pressure was observed in the oestradiol-treated compared to the vehicle-treated group, together with a significant increase in red cell [Na+]. Oestradiol administration produced no significant changes in total Na+ influx, cotransport, countertransport or Na+ diffusion and did not alter plasma [Na+], red cell [K+], mean corpuscular haemoglobin concentration (MCHC) or blood volume per 100g body weight. However, significant decreases in body weight, haematocrit and plasma [K+] were observed in the oestradiol-treated group. These results support previous observations that oestradiol increases blood pressure and suggest that chronic administration of oestrogen increases red cell [Na+], probably by a mechanism other than alteration in erythrocyte passive Na+ transport.
人红细胞中 Na-K-Cl 共转运的不对称性。
DOI：
10.1152/ajpcell.1988.254.2.c243
发表时间：
1988
期刊：
The American journal of physiology
影响因子：
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作者：
Kracke,GR;Anatra,MA;Dunham,PB
通讯作者：
Dunham,PB