The Genetics of Functional Disability in Schizophrenia and Bipolar Illness: Methods and Initial Results for VA Cooperative Study #572
The Genetics of Functional Disability in Schizophrenia and Bipolar Illness: Methods and Initial Results for VA Cooperative Study #572
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DOI：
10.1002/ajmg.b.32242
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发表时间：
2014-06-01
影响因子：
2.8
通讯作者：
Concato, John
中科院分区：
文献类型：
--
作者：
Harvey, Philip D.;Siever, Larry J.;Concato, John
鉴于与精神分裂症和双相情感障碍相关的认知障碍和残疾的突出性，人们对确定这些疾病及其特征的决定因素产生了浓厚的兴趣。遗传变异与造成残疾的技能（“功能能力”或 FC）有关，这凸显了理解这些关系的必要性。我们描述了一项大型、多地点、观察性研究的设计和方法，该研究重点关注精神分裂症和双相情感障碍的功能障碍遗传学，提供有关招募和样本特征的初步数据。这项研究被称为退伍军人事务部 (VA) 合作研究计划 (CSP)#572，正在招募、诊断和评估患有精神分裂症或 I 型双相情感障碍的美国退伍军人。评估包括神经心理学 (NP) 测试、FC、自杀倾向以及创伤后应激障碍 (PTSD) 等共病。来自另一个项目的“精神健康”退伍军人样本作为对照组。截至 2013 年 9 月 30 日，已临时招募和评估了 8,140 名参与者（42.1% 患有精神分裂症），还剩 9 个月的时间，目标样本量为 9,500 人。患有精神分裂症的退伍军人更有可能从未结婚，而终生创伤后应激障碍和自杀倾向在躁郁症退伍军人中更为常见。 FC 测量和 NP 测试的表现与之前的结果一致，精神分裂症的平均 t 分数为 35 (-1.5 SD)，双相情感障碍退伍军人的平均 t 分数为 41 (-0.9 SD)。这个庞大的人群在患者表现和合并症方面代表了先前的研究。随后的基因组分析将检查基于表现的测量的基因组相关性。 2014 年发表。本文是美国政府的作品，在美国属于公共领域。
Given the prominence of cognitive impairments and disability associated with schizophrenia and bipolar disorder, substantial interest has arisen in identifying determinants of the diseases and their features. Genetic variation has been linked to skills that underlie disability ("functional capacity" or FC), highlighting need for understanding of these relationships. We describe the design and methods of a large, multisite, observational study focusing on the genetics of functional disability in schizophrenia and bipolar disorder, presenting initial data on recruitment, and characterization of the sample. Known as Veterans Affairs (VA) Cooperative Studies Program (CSP)#572, this study is recruiting, diagnosing, and assessing U.S. Veterans with either schizophrenia or bipolar I disorder. Assessments include neuropsychological (NP) testing, FC, suicidality, and co-morbid conditions such as posttraumatic stress disorder (PTSD). A sample of "psychiatrically healthy" Veterans from another project serves as a comparison group. An interim total of 8,140 participants (42.1% schizophrenia) have been recruited and assessed as of September 30, 2013, with 9 months of enrollment remaining and with a target sample size of 9,500. Veterans with schizophrenia were more likely to never have married, whereas lifetime PTSD and suicidality were more common in the bipolar veterans. Performance on the FC measures and NP tests was consistent with previous results, with mean t-scores of 35 (-1.5 SD) for schizophrenia and 41 (-0.9 SD) for the bipolar Veterans. This large population is representative of previous studies in terms of patient performance and co-morbidities. Subsequent genomic analyses will examine the genomic correlates of performance-based measures. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.