Biocompatibility of poly-DL-lactic acid (PDLLA) for lung tissue engineering
Biocompatibility of poly-DL-lactic acid (PDLLA) for lung tissue engineering
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DOI：
10.1177/0885328206057952
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发表时间：
2006-10-01
影响因子：
2.9
通讯作者：
Bishop, A. E.
中科院分区：
文献类型：
--
作者：
Lin, Y. M.;Boccaccini, A. R.;Bishop, A. E.
这项研究探讨了在聚DL-乳酸（PDLLA）支架上生长肺细胞的可能性，以期将来设计用于人体植入的肺组织。作为该过程的第一步，使用稳健的细胞系测试 PDLLA 维持肺上皮生长的能力。聚-DL-乳酸以两种形式进行了研究，即平面盘和 3-D 泡沫，并已证明 PDLLA 不仅对肺细胞无毒，而且还积极支持其生长。初步研究结果表明，该材料是远端肺组织工程的合适基质。
This study explores the possibility of growing lung cells on poly-DL-lactic acid (PDLLA) scaffolds, with a view to in future engineer pulmonary tissue for human implantation. As a first step in this process, the ability of PDLLA to maintain the growth of lung epithelium is tested using a robust cell line. Poly-DL-lactic acid has been investigated in two forms, as planar discs and as 3-D foams, and it has been demonstrated that PDLLA is not only nontoxic to pneumocytes but it also actively supports their growth. The initial findings suggest that the material is an appropriate matrix for engineering of distal lung tissue.