Early bilateral sensory deprivation blocks the development of coincident discharge in rat barrel cortex.
Early bilateral sensory deprivation blocks the development of coincident discharge in rat barrel cortex.
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DOI：
10.1523/jneurosci.4427-08.2009
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发表时间：
2009-02-25
期刊：
影响因子：
--
通讯作者：
Ebner F
中科院分区：
文献类型：
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作者：
Ghoshal A;Pouget P;Popescu M;Ebner F
一些理论提出了同步神经元放电在产生感官知觉的神经代码中的功能作用。同步神经活动在产后皮质成熟的关键时期发展，在此期间感觉通路中的神经活动严重减少可能会干扰皮质神经元之间同步放电的发展。这种同步性的丧失可能为行为研究中显示的敏锐度下降提供了一个基本机制。我们测试的假设，桶皮层神经元的同步放电将无法开发后，感觉剥夺双侧胡须修剪从出生到P-60。通过研究皮层神经元对的相关放电，我们发现了对照组动物中强相关放电的证据，而在剥夺动物的皮层桶神经元对中几乎不存在这种同步。大鼠桶状皮层各亚区的同步性受损程度不同。最符合数据的模型是，从初级感觉（丘系）通路接收直接输入的皮层神经元在感觉剥夺后同步性下降最大，而从丘脑和皮层其他区域接收不同输入的神经元在皮层功能的这一维度上受到的影响相对较小。
Several theories have proposed a functional role for synchronous neuronal firing in generating the neural code of a sensory perception. Synchronous neural activity develops during a critical postnatal period of cortical maturation, and severely reducing neural activity in a sensory pathway during this period could interfere with the development of coincident discharge among cortical neurons. Loss of such synchrony could provide a fundamental mechanism for the degradation of acuity shown in behavioral studies. We tested the hypothesis that synchronous discharge of barrel cortex neurons would fail to develop after sensory deprivation produced by bilateral whisker trimming from birth to P-60. By studying the correlated discharge of cortical neuron pairs we found evidence for strong correlated firing in control animals, and this synchrony was almost absent among pairs of cortical barrel neurons in deprived animals. The degree of synchrony impairment was different in sub-regions of rat barrel cortex. The model that best fits the data is that cortical neurons receiving direct inputs from the primary sensory (lemniscal) pathway show the greatest decrement in synchrony following sensory deprivation, while neurons with diverse inputs from other areas of thalamus and cortex are relatively less affected in this dimension of cortical function.