Pathophysiology of venous thrombosis
Pathophysiology of venous thrombosis
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DOI：
10.1016/s0049-3848(09)70140-9
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发表时间：
2009-01-01
影响因子：
7.5
通讯作者：
Chen, Junmei
中科院分区：
文献类型：
--
作者：
Lopez, Jose A.;Chen, Junmei
以Virchow's triad为框架，很明显，其任何组成部分（血液成分、血管壁和血流）的改变都可能影响静脉血栓栓塞的发展倾向。每一个也可以影响其他方式，增强或减少血栓倾向。虽然过去的研究主要集中在影响血栓形成的血液成分上，但它们的影响通常只在血栓形成过程开始后才显现出来，而对血管中血栓形成的开始了解得最少。这篇简短的综述试图将诸如停滞和癌症等危险因素与引发血栓形成的机制联系起来。2009爱思唯尔有限公司版权所有。
Using Virchow's triad as framework, it is clear that alterations in any of its components (blood composition, the vessel wall, and blood flow) can influence the propensity for the development of venous thromboembolism. Each can also influence the others in ways that enhance or reduce thrombotic propensity. While past work has concentrated on blood components that influence thrombogenicity, their influences generally are manifest only after the thrombotic process has begun, and it is initiation of thrombosis on the vessel watt that is the least well understood. This brief review attempts to link risk factors such as stasis and cancer to the mechanisms that initiate thrombosis. (C) 2009 Elsevier Ltd. All rights reserved.