Mouse models and the evolutionary developmental biology of the skull
Mouse models and the evolutionary developmental biology of the skull
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DOI：
10.1093/icb/icn076
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发表时间：
2008-09-01
影响因子：
2.6
通讯作者：
Lieberman, Daniel E.
中科院分区：
文献类型：
--
作者：
Hallgrimsson, Benedikt;Lieberman, Daniel E.
理解发育与理解进化是相关的，因为发育过程构建了自然选择作用的表型变异的表达。发育生物学的进步推动了发育生物学和进化生物学的新综合，但如何利用主要来自少数模式生物的发育信息来检验关于类群（如人类和其他灵长类动物）进化发育生物学的假设仍然不清楚，这些类群还没有或不适合通过实验发育生物学进行直接研究。在这篇文章中，我们讨论了像老鼠这样的模式生物如何以及何时对研究像灵长类这样的远亲和形态不同的群体的进化发育生物学有用。一种富有成效的方法是关注在大系统发育范围内产生进化上显著的表型变异中可能发挥关键作用的过程。我们通过将小鼠突变模型的颅面变异分析应用于灵长类动物和人类进化来说明这种方法。
Understanding development is relevant to understanding evolution because developmental processes structure the expression of phenotypic variation upon which natural selection acts. Advances in developmental biology are fueling a new synthesis of developmental and evolutionary biology, but it remains unclear how to use developmental information that largely derives from a few model organisms to test hypotheses about the evolutionary developmental biology of taxa Such as humans and other primates that have not been or are not amenable to direct study through experimental developmental biology. In this article, we discuss how and when model organisms like mice are useful for Studying the evolutionary developmental biology of even rather distantly related and morphologically different groups like primates. A productive approach is to focus on processes that are likely to play key roles in producing evolutionarily significant phenotypic variation across a large phylogenetic range. We illustrate this approach by applying the analysis of craniofacial variation in Mouse Mutant models to primate and human evolution.