Reduced activity in the extrastriate visual cortex of individuals with strabismic amblyopia
Reduced activity in the extrastriate visual cortex of individuals with strabismic amblyopia
复制标题
斜视性弱视患者的纹状体外视皮层活动减少
DOI：
10.1016/s0304-3940(97)00211-5
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发表时间：
1997
影响因子：
2.5
通讯作者：
B. Långström
中科院分区：
文献类型：
--
作者：
K. Imamura;H. Richter;H. Fischer;G. Lennerstrand;O. Franzén;A. Rydberg;J. Andersson;H. Schneider;H. Onoe;Yasuyoshi Watanabe;B. Långström
为探讨斜视性弱视患者视力下降与皮质激活模式的关系，我们采用正电子发射断层扫描（PET）和H215 O团注技术，研究了8例斜视性弱视患者单眼视觉刺激引起的局部脑血流量（rCBF）的变化。在PET扫描期间，采用用于单眼检测棋盘图案的个体弱视阈值作为双眼的刺激。减影图像的统计学分析显示，刺激双侧Brodmann区（BA）17-19的健眼，rCBF显著增加（P<0.05）。弱视眼诱发的皮层反应在同侧BA 18、19中显著降低（P<0.05）。这些结果表明，弱视的对比敏感度（图案视觉）降低与枕骨视觉区的可识别区域（包括同侧BA）失活相关18，19。
In order to examine the relationship between reduced visual acuity in human strabismic amblyopia and the cortical activation pattern, we studied, by use of positron emission tomography (PET) and the H215O bolus technique, changes in the regional cerebral blood flow (rCBF) induced by monocular visual stimulation of 8 individuals with this disorder. Individual amblyopic thresholds for monocular detection of the checkerboard pattern were employed as stimuli for both eyes during PET scans. Statistical analysis of subtracted images showed significant increases in rCBF (P<0.05) by the stimulation of the sound eye localized bilaterally to Brodmann's areas (BAs) 17–19. The cortical response evoked by the amblyopic eye was significantly reduced (P<0.05) in the ipsilateral BAs 18,19. These results suggest that the reduction in contrast sensitivity (pattern vision) in amblyopia is coupled with deactivation in identifiable regions of occipital visual areas, including ipsilateral BAs 18,19.
眼优势可塑性：麻醉和麻痹制剂的有用性。
DOI：
10.2170/jjphysiol.41.521
发表时间：
1991
期刊：
The Japanese journal of physiology
影响因子：
--
作者：
Imamura,K;Kasamatsu,T
通讯作者：
Kasamatsu,T
正电子发射断层扫描对弱视脑血流和代谢的成像。
影响因子：
4.2
作者：
Demer,JL;vonNoorden,GK;Volkow,ND;Gould,KL
通讯作者：
Gould,KL