Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer
Lumpectomy plus tamoxifen with or without irradiation in women 70 years of age or older with early breast cancer
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DOI：
10.1056/nejmoa040587
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发表时间：
2004-09-02
影响因子：
158.5
通讯作者：
Norton, L
中科院分区：
文献类型：
--
作者：
Hughes, KS;Schnaper, LA;Norton, L
背景：在70岁或以上的妇女谁有早期乳腺癌，目前还不清楚是否乳房肿瘤切除术加他莫昔芬是有效的乳房肿瘤切除术后，他莫昔芬加radiotherapy.METHODS：在1994年7月和1999年2月，我们随机分配636名妇女谁是70岁或以上，谁有临床阶段I（T1N0M0根据肿瘤淋巴结转移分类），雌激素受体阳性乳腺癌治疗的乳房肿瘤切除术接受他莫昔芬加放疗（317名妇女）或他莫昔芬单独（319名妇女）。主要终点是局部或区域复发的时间，复发乳房切除术的频率，乳腺癌特异性生存率，远处转移的时间和总生存率。结果：两组之间唯一的显著差异是5年时局部或区域复发率（他莫昔芬联合放疗组为1%，单用他莫昔芬组为4%，P
BACKGROUND:In women 70 years of age or older who have early breast cancer, it is unclear whether lumpectomy plus tamoxifen is as effective as lumpectomy followed by tamoxifen plus radiation therapy.METHODS:Between July 1994 and February 1999, we randomly assigned 636 women who were 70 years of age or older and who had clinical stage I (T1N0M0 according to the tumor-node-metastasis classification), estrogen-receptor-positive breast carcinoma treated by lumpectomy to receive tamoxifen plus radiation therapy (317 women) or tamoxifen alone (319 women). Primary end points were the time to local or regional recurrence, the frequency of mastectomy for recurrence, breast-cancer-specific survival, the time to distant metastasis, and overall survival.RESULTS:The only significant difference between the two groups was in the rate of local or regional recurrence at five years (1 percent in the group given tamoxifen plus irradiation and 4 percent in the group given tamoxifen alone, P